Question

A series of chromosomal rearrangements take place on a chromosome over time. The initial chromosome gene sequence is: RNA • EGR (• = centrosome)

What is the final gene sequence, and where is the centrosome? Note: this is one problem, listed below is the order that it is supposed to go in.

a. There is a tandem duplication E.

b. There is a pericentric inversion of the segment from A to G.

c. There is a reverse duplication of the AR segment.

d. There is a translocation of the NGE segment to the right end of the chromosome.

Answer 1

Original chromosome arrangement: RNA-EGR

Tandem repeat of E :RNA-EEGR

Pericentric inversion from A to G: RNGEE-AR

It involves reversal of chromosome fragment.

Reverse duplication of AR: RNGEE-ARRA

Translocation of NGE segment: RE-ARNGE

It change in position of chromosomes