During gluconeogenesis, why would the cell want to have the function of the fructose-6- bisphosphate phosphatase...
During gluconeogenesis, why would the cell want to have the function of the fructose-6-
bisphosphate phosphatase be negatively regulated by high levels of AMP?
Homework Answers
fructose 1,6-bisphosphatase converts fructose 1,6-bisphosphate to fructose 6-phosphate in gluconeogenesis. this enzyme is negatively controlled by high levels of AMP, i.e, high levels of AP inhibits the action of this enzyme.
when the cell has high levels of AMP (which means a low concentration of ATP), it needs to produce ATP. ATP is produced in the glycolytic pathway (gluconeogenesis requires ATP). under this condition, it is clear that the cell needs glycolysis but not gluconeogenesis. hence, it inhibits fructose 1,6-bisphosphatase, thereby inhibiting gluconeogenesis.
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During gluconeogenesis, why would the cell want to have the
function of the fructose-6-
bisphosphate phosphatase...
During the EMP pathway, why would the cell want the pyruvate kinase be positively regulated by...
During the EMP pathway, why would the cell want the pyruvate kinase be positively regulated by high levels of fructose-6-phosphate?
After eating, elevated levels of fructose 6-phosphate will stimulate ["phosphoprotein phosphatase or Protein kinase A (PKA)"]....
After eating, elevated levels of fructose 6-phosphate will stimulate ["phosphoprotein phosphatase or Protein kinase A (PKA)"]. This causes the dephosphorylation of the the phosphofructokinase 2/fructose 2,6-bisphosphate polypeptide to stimulate the activity of ["phosphofructokinase 2 or fructose 2,6-bisphosphatase"].This results in an increase of ["fructose 6-phosphate or fructose 2,6-bisphosphate"] and activation of ["glycolysis or gluconeogenesis"] . Choose one of the answers in the brackets.
Why are these reactions for gluconeogenesis exergonic? I get that Glucose 6-phosphate -> glucose and fructose...
Why are these reactions for gluconeogenesis
exergonic?
I get that Glucose 6-phosphate -> glucose and fructose
1,6-biphosphate -> fructose 6 phosphate release Pi, but doesn't
the formation of formation of oxaloacetate and phosphoenolpyruvate
require energy ( ATP and GTP)
ruvate. CH,OH CHOPO; HO он glucose 6- phosphatase HO OH OH 94 Он glucose 6-phosphate glucose glycolysao OPOH COCHZOPO HO O HO OH fructose 1,6- bisphosphatase ,POH COCH,OH HO он OH fructose 6-phosphate OH fructose 1,6-bisphosphate HCO; + ATP ADP +...
Question 4 Q . OH ATP OH POH ОН Fructose 6-phosphate Fructose 1.6-bisphosphate Figure 1. Reaction...
Question 4 Q . OH ATP OH POH ОН Fructose 6-phosphate Fructose 1.6-bisphosphate Figure 1. Reaction catalyzed by phosphofructokinase (PFK) during glycolysis Phosphofructokinase (PFK) is an enzyme that catalyzes the conversion of fructose 6- phosphate to fructose 1,6-bisphosphate during glycolysis, as represented in Figure 1. PFK can be allosterically inhibited by ATP at high concentrations. Which of the following is the benefit of regulating glycolysis by the concentration of ATP? Glycolysis proceeds when the intracellular concentration of ATP is low,...
match the following 1. Fructose 1,6-bisphosphate is converted to Fructose 6- phosphate through this enzyme _____...
match the following 1. Fructose 1,6-bisphosphate is converted to Fructose 6- phosphate through this enzyme _____ 2. Synthesis of glucose from noncarbohydrate precursors _____ 3. Stage in which two molecules of ATP are consumed _____ 4. This is formed from pyruvate in yeast and several other microorganisms through fermentation _____ 5. The isomerization of glucose 6-phosphate to fructose 6-phosphate is a coversion of an aldose into a …._____ 6. Pyruvate is converted by pyruvate carboxylase into this intermediate _____ 7....
The primary regulatory point of gluconeogenesis is____? a. glucose-6-phosphatase b. fructose-1,6-biphosphatase c. fuctose-2,6-biphosphatase d. pyruvate carboxylase...
The primary regulatory point of gluconeogenesis is____? a. glucose-6-phosphatase b. fructose-1,6-biphosphatase c. fuctose-2,6-biphosphatase d. pyruvate carboxylase (wrong answer) e. PEP carboxykinase Please explain why pyruvate carboxylase is wrong (isn't it one of the regulatory points, is it wrong because it isn't the primary one? and if so, how do you know what the primary one is?) and state the right answer and an explanation as to why.
Explain in detail how PFK-1, hexokinase, glucokinase, pyruvate kinase, glucose-6-phosphatase, fructose-1,6-bisphosphatase-1, pyruvate carboxylase & PEPCK are...
Explain in detail how PFK-1, hexokinase, glucokinase, pyruvate kinase, glucose-6-phosphatase, fructose-1,6-bisphosphatase-1, pyruvate carboxylase & PEPCK are regulated & compare their regulation in liver vs. skeletal muscle & brain when blood glucose levels are high (i.e. a fed state) & low (i.e. a fasting or starvation state).
6. An organism is found to have an alternative enzyme step in glycolysis, shown below: Fructose-1,6-bisphosphate...
6. An organism is found to have an alternative enzyme step in glycolysis, shown below: Fructose-1,6-bisphosphate -> two 1,3-bisphosphoglycerate a. Write the corresponding reactions this would replace in glycolysis b. Would glycolysis in this organism be more efficient? c. Would other pathways or other parts of the cell be affected by this change?
A highly regulated reaction in glycolysis involves the addition of a second phosphate to fructose-6-phosphate, which...
A highly regulated reaction in glycolysis involves the addition
of a second phosphate to fructose-6-phosphate, which could be be
written as:
Fructose-6-phostphate + Pi à Fructose-1,6-bisphosphate + H2O
The ∆Go’ for this reaction is +16.8 kJ/mol
In a muscle cell at 37 oC, assume the concentration of
Fructose-6phosphate is 0.014 mM and the concentration of phosphate
is 1 mM.
a. What would be the equilibrium concentration of
fructose-1,6bisphosphate under these conditions?
b. What is Keq for this reaction?
Show...
During clinical rounds, you encounter patients who exhibit defects that affect gluconeogenesis. Predict the effect that...
During clinical rounds, you encounter patients who exhibit defects that affect gluconeogenesis. Predict the effect that each of the following conditions/defects would have on gluconeogenesis. Explain your prediction and indicate what life style change the patient might make to alleviate the symptoms. a) Patient 1 exhibits a deficiency of the liver lactate dehydrogenase activity. b) Patient 2 exhibits defective liver glucagon receptors which cannot bind glucagon. c) Patient 3 exhibits a constitutively phosphorylated liver phosphofructokinase-2 to lock the bifunctional enzyme...
Why are these reactions for gluconeogenesis
exergonic?
I get that Glucose 6-phosphate -> glucose and fructose
1,6-biphosphate -> fructose 6 phosphate release Pi, but doesn't
the formation of formation of oxaloacetate and phosphoenolpyruvate
require energy ( ATP and GTP)
ruvate. CH,OH CHOPO; HO он glucose 6- phosphatase HO OH OH 94 Он glucose 6-phosphate glucose glycolysao OPOH COCHZOPO HO O HO OH fructose 1,6- bisphosphatase ,POH COCH,OH HO он OH fructose 6-phosphate OH fructose 1,6-bisphosphate HCO; + ATP ADP +...
Question 4 Q . OH ATP OH POH ОН Fructose 6-phosphate Fructose 1.6-bisphosphate Figure 1. Reaction catalyzed by phosphofructokinase (PFK) during glycolysis Phosphofructokinase (PFK) is an enzyme that catalyzes the conversion of fructose 6- phosphate to fructose 1,6-bisphosphate during glycolysis, as represented in Figure 1. PFK can be allosterically inhibited by ATP at high concentrations. Which of the following is the benefit of regulating glycolysis by the concentration of ATP? Glycolysis proceeds when the intracellular concentration of ATP is low,...
A highly regulated reaction in glycolysis involves the addition
of a second phosphate to fructose-6-phosphate, which could be be
written as:
Fructose-6-phostphate + Pi à Fructose-1,6-bisphosphate + H2O
The ∆Go’ for this reaction is +16.8 kJ/mol
In a muscle cell at 37 oC, assume the concentration of
Fructose-6phosphate is 0.014 mM and the concentration of phosphate
is 1 mM.
a. What would be the equilibrium concentration of
fructose-1,6bisphosphate under these conditions?
b. What is Keq for this reaction?
Show...
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