The protein “P” binds to the protein “L” with an association rate (ka) of 8.9 x...
The protein “P” binds to the protein “L” with an association rate (ka) of 8.9 x 103 M-1s-1 and an overall dissociation constant, Kd, of 10 nM. Calculate the dissociation rate, kd, including appropriate units. Show allllllll work Please.
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The protein “P” binds to the protein “L” with an association
rate (ka) of 8.9 x...
1. What does it mean to have positive cooperatively in protein-ligand binding? 2. The protein “Mariota”...
1. What does it mean to have positive cooperatively in protein-ligand binding? 2. The protein “Mariota” binds to the ligand “football” with an association rate of 8.0 x 10 103M-1s-1 and an overall dissociation constant, Kd of 10 nM. Calculate the dissociation rate, kd, including appropriate units. 3. An antibody binds to an antigen with a Kd of 8 X 10-6M. At what concentration of antigen will the fractional saturation (Υantigen) be (a) 0.2, (b) 0.5, (c) 0.6, and (d)...
SHOW WORK: theprofein Calmodulin th an association rate of 89 X103N'5-1 and an overall dissoctation constant...
SHOW WORK:
theprofein Calmodulin th an association rate of 89 X103N'5-1 and an overall dissoctation constant Ckd) of 1ONM. ORverse of Lioand Binding: Coldineurin binds to Now show the sleps of dissociation rate Kd & include the appropriate units. Reverse of Ligand Bineng Now a binding protein the concentration of Ligand hen Y is equal to 0.25 (b)0. b.95? 3 Reverse bindi ng to an Antibody The anti body bires to an Jahow the tps at what Concentration of ANTIGEN...
Wrine a rate equation depicting the rate of change in the concentration of the protein ligand...
Wrine a rate equation depicting the rate of change in the concentration of the protein ligand eomples formedi acvonding to the reaction below e5 pts ndng Se LP L+P k Protein (P) Protein (P) The reaction above has a 2 onder association rate constant (k.) of 500 mM's and a 1" order dissociation rate constant (ka) of 10 s, What are the equilibrium association (KA) and dissociation (Kn) constants for this basic ligand binding event (I BP) 2.) Use the...
Short answer questions: 21. Protein A has a binding site for ligand L with a Ka...
Short answer questions: 21. Protein A has a binding site for ligand L with a Ka of 10-6 M. Protein B has a binding site for ligand L with a Ka of 10'M. (a). Which protein has a higher affinity for ligand L? Explain your reasoning. (b). At what concentration of ligand L is proteins A half-saturated. At what concentration of L is protein B half-saturated. [L] y = [L] + Ka 22. A protein binds to a ligand L...
Question 1 (1 point) Vasoconstriction occurs when epinephrine (adrenaline) binds to the a-adrenergic receptor on vascular...
Question 1 (1 point) Vasoconstriction occurs when epinephrine (adrenaline) binds to the a-adrenergic receptor on vascular smooth muscle cells. One way to treat high blood pressure is to administer competitive inhibitors that bind to this receptor. The Kd for binding of epinephrine to this receptor is ~UM. Based on the measured affinity (Kd) of the following drugs for the a-adrenergic receptor, which might be good candidates for high blood pressure medication? Drug A: Kd = 0.6 M; Drug B: Kd...
Calculate Ka for 1 M NaCH3COO pH = 9.37 H+ = 4.203 X 10^-10 OH- =...
Calculate Ka for 1 M NaCH3COO pH = 9.37 H+ = 4.203 X 10^-10 OH- = 2.402 X 10^-5 CH3COO- = 1.00 X 10^0 CH3COOH = 2.402 X 10^-5 ________________ Calculate Ka using the formula Kw = Ka X Kb and the appropriate equilibrium constant for 1 M NaCH3COO. NaCH3COO ---> Na+ (neutral) + CH3COO-. Is the conjugate base for CH3COOH. CH3COOH Ka1 = 1.8 X 10^-5 ______________________ Calculate Ka for 1 M NH4Cl pH = 4.26 H+ = 2.336...
he solubility product (Ksp) of PbBr2 is 8.9 X 10. Please calculate the molar solubility in:...
he solubility product (Ksp) of PbBr2 is 8.9 X 10. Please calculate the molar solubility in: A) Pure water B) 0.20 M Pb(NOs)2 Pb Brs) Pbap +2 Br 8.9- M0T 2 LOZJLES . 45 25 O.Zts Zs 4.45./05 4 4s 0.2x0.2+s 13:105- J S0-60334 9. The solubility of an ionic compound MX (molar mass = 346 g/mol) is 4.63 X 103 g/L. What is the Ksp for this compound? HoW
Similar to the lecture, our example is a drug molecule D and a drug target enzyme...
Similar to the lecture, our example is a drug molecule D and a drug target enzyme E. The drug target enzyme E is commonly found in concentrations [E]tot of 250 nM, i.e. 2.5 x 10-7 mol/l. The drug D binds to E to form the complex ED with a dissociation constant of KD = 1.30 µM (i.e. 1.30 x 10-6). The dissociation constant has been determined at room temperature, i.e. for T = 298.15 K. 1. In order to estimate...
13. For the following reaction: A P experimental kinetic data show that the overall reaction order is one-half. And 500...
13. For the following reaction: A P experimental kinetic data show that the overall reaction order is one-half. And 500 s after initiation of the reaction, the reactant decreased from 1.0 M to 0.35 M. Calculate the rate constant 1.6 x 103 s A) В) 3.3 x 10-5 S-1 С) 5.1 х 103 s-1 D) 3.3 x 10-5 s-1 1.1 x 10-3 s E)
Use the data in the table below to determine the rate constant (in L mol-1s-1) for...
Use the data in the table below to determine the rate constant (in L mol-1s-1) for the reaction below? 2?2(?)+?2(?)⇌2?2?(?) 2 H 2 ( g ) + O 2 ( g ) ⇌ 2 H 2 O ( g ) Experiment [H2]0 (M) [O2]0 (M) Initial rate (M s-1) 1 2.5 x 10-2 1.0 x 10-2 4 2 5.0 x 10-2 1.0 x 10-2 8 3 2.5 x 10-2 0.5 x 10-2 2 Select one: a. 1.2 x 103 3...
SHOW WORK:
theprofein Calmodulin th an association rate of 89 X103N'5-1 and an overall dissoctation constant Ckd) of 1ONM. ORverse of Lioand Binding: Coldineurin binds to Now show the sleps of dissociation rate Kd & include the appropriate units. Reverse of Ligand Bineng Now a binding protein the concentration of Ligand hen Y is equal to 0.25 (b)0. b.95? 3 Reverse bindi ng to an Antibody The anti body bires to an Jahow the tps at what Concentration of ANTIGEN...
Wrine a rate equation depicting the rate of change in the concentration of the protein ligand eomples formedi acvonding to the reaction below e5 pts ndng Se LP L+P k Protein (P) Protein (P) The reaction above has a 2 onder association rate constant (k.) of 500 mM's and a 1" order dissociation rate constant (ka) of 10 s, What are the equilibrium association (KA) and dissociation (Kn) constants for this basic ligand binding event (I BP) 2.) Use the...
Short answer questions: 21. Protein A has a binding site for ligand L with a Ka of 10-6 M. Protein B has a binding site for ligand L with a Ka of 10'M. (a). Which protein has a higher affinity for ligand L? Explain your reasoning. (b). At what concentration of ligand L is proteins A half-saturated. At what concentration of L is protein B half-saturated. [L] y = [L] + Ka 22. A protein binds to a ligand L...
Question 1 (1 point) Vasoconstriction occurs when epinephrine (adrenaline) binds to the a-adrenergic receptor on vascular smooth muscle cells. One way to treat high blood pressure is to administer competitive inhibitors that bind to this receptor. The Kd for binding of epinephrine to this receptor is ~UM. Based on the measured affinity (Kd) of the following drugs for the a-adrenergic receptor, which might be good candidates for high blood pressure medication? Drug A: Kd = 0.6 M; Drug B: Kd...
he solubility product (Ksp) of PbBr2 is 8.9 X 10. Please calculate the molar solubility in: A) Pure water B) 0.20 M Pb(NOs)2 Pb Brs) Pbap +2 Br 8.9- M0T 2 LOZJLES . 45 25 O.Zts Zs 4.45./05 4 4s 0.2x0.2+s 13:105- J S0-60334 9. The solubility of an ionic compound MX (molar mass = 346 g/mol) is 4.63 X 103 g/L. What is the Ksp for this compound? HoW
13. For the following reaction: A P experimental kinetic data show that the overall reaction order is one-half. And 500 s after initiation of the reaction, the reactant decreased from 1.0 M to 0.35 M. Calculate the rate constant 1.6 x 103 s A) В) 3.3 x 10-5 S-1 С) 5.1 х 103 s-1 D) 3.3 x 10-5 s-1 1.1 x 10-3 s E)
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