What experiments were the "Find it, Lose it, and Move It" demonstrating that mesenchyme is necessary and sufficient for lung branching morphogenesis.
Proper lung functioning requires not only a correct structure of the conducting airway tree, but also the simultaneous development of smooth muscles and vasculature. Lung branching morphogenesis is strongly stereotyped and involves the recursive use of only three modes of branching. We have previously shown that the experimentally described interactions between Fibroblast growth factor (FGF)10, Sonic hedgehog (SHH) and Patched (Ptc) can give rise to a Turing mechanism that not only reproduces the experimentally observed wildtype branching pattern but also, in part counterintuitive, patterns in mutant mice. Here we show that, even though many proteins affect smooth muscle formation and the expression of Vegfa, an inducer of blood vessel formation, it is sufficient to add FGF9 to the FGF10/SHH/Ptc module to successfully predict simultaneously the emergence of smooth muscles in the clefts between growing lung buds, and Vegfa expression in the distal sub-epithelial mesenchyme. Our model reproduces the phenotype of both wildtype and relevant mutant mice, as well as the results of most culture condition.
What experiments were the "Find it, Lose it, and Move It" demonstrating that mesenchyme is necessary...
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-8 0 Find -4A. -4A Let A5 -8 0 Find-3A LetA-7 3 and Ba Find -3A+48 -3A+4B LetA-73 8 9 and B4-6 4 -6 Find a matrix X satistying the given equation (Simplity your answer) 10. When ticket holders fail to attend, sports teams lose the money these fans would have spent on refreshments, souvenirs, etc. The percentage of fans who don't show up is 12% in baskeeal and hockey, 13% in footbaL and 18% n basebal me lost revenue...
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Question 1 (15 polnts) Consider the following simultaneous-move game Player 2 ILIR T15. 2 | 2,0 B 3,30, 5 A. Find the pure-strategy Nash equilibrium of this game. Player M B. Can player 2 help himself by employing a simple unconditional strategie move? If so, what action will player 2 choose to commit to? What are the players' new payoffs? C. Answer the following question only if your were not able to find an unconditional strategic move. Can player 2...
What management skill do you find most necessary for effective and efficient project management? Why?
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