1. A bacterium, which is pathogenic to humans, loses its capsule through a mutation. (a)How do...
1. A bacterium, which is pathogenic to humans, loses its capsule through a mutation. (a)How do you think this will affect its ability to infect humans?(b)What if, through mutation, the bacterium could no longer make LPS?
Homework Answers
Capsule is extracellular polysaccharide secreted by many bacteria. Mostly capsules are hydrophilic and help the bacteria to avoid desiccation by preventing dehydration. It also protects the bacteria from destruction by WBCs and ultimately to escape engulfment by phagocytic cells, i.e., macrophages.
A. If the mutant strain loses its capsule, the bacteria will lose its infective or invasive ability, known as virulence, and can be readily phagocitized by White Blood Cells and will not cause disease.
B. LPS is not needed for bacterial growth . It protects bacteria from antibiotics and complement-mediated lysis and defence against host immune response. It also protects the outer membrane from chemical or enzymatic attack. If the bacteria can't synthesize LPS it will no longer be able to cause toxic effect of the bacterial disease and can be degraded easily by host immune system.
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1. A bacterium, which is pathogenic to humans, loses its capsule
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Can someone please walk me through how to do this?
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Name = deletions 7this tes whether 10. Seven non-reverting mutations at the nii locus of T4 were used to co-infect E.coli strain B at high multiplicity of infection. The lysates from each co-infection were then in spotted onto a lawn of strain K to test whether they could infect and lyse strain K. The results of this test are shown in the following table, where "+" indicates lysis of strain...
Please answer all!! Thank you :)
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