Pure malathion has minimal toxicity in rats, but the presence of very small amounts of impurities...
Pure malathion has minimal toxicity in rats, but the presence of very small amounts of impurities causes the toxicity to increase considerably. This is an example of what type of effect? Name the effect and relate it to this situation.
Homework Answers
Malathion affects the nervous the nervous system of animals due to which it is unclassifiable. Malathion is an organophosphate group of insecticides and it can kill mosquitoes and other insects. To find out the chronic toxicity of melathion an experiment was performed with rats by continuous exposure to malathion.
Pure malathion has minimal toxicity in rats, but the presence of very small amount of impurities causes the toxicity to increase considerably. This effect comes under the inhibition of AChE activity. Due to its low toxicity malathion has been used as an insecticide with different application for many years. Malathion exhibits low mammalian toxicity and relevant impurities may increase toxicity, so it is necessary to know the impurity profile of malathion. Some necessary bioactivation to malaoxon results in a delay in which other metabolic reactions takes place. As a result formation of MMCA and MDCA dominates it's metabolism in rats.
Due to the sensitivity of RBC AChE to malathion exposure, it has been selected as endpoint for use in risk assessment. Malathion doesn't have any impact on reproduction.
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Pure malathion has minimal toxicity in rats, but the presence of
very small amounts of impurities...
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