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Can the Krebs cycle active produce NADH at the same time as gluconeogenesis is actively producing...

Can the Krebs cycle active produce NADH at the same time as gluconeogenesis is actively producing glucose? Explain. [hint: Consider if there are regulatory mechanisms or limited abundance of metabolites that would limit both pathways being active simultaneously.]

can you keep the answer in a paragraph, and as brief  as possible

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Answer #1

The answer is NO.

After the production of glucose from gluconeogenesis,glucose is then converted into two Pyruvate, two NADH, and two ATP.And this Pyruvate is again converted into Acetyl Co A to enter the citric acid cycle(Krebs cycle).Only after this step ,they can produce NADH.

So,gluconeogenesis,glycolysis and Krebs cycle cannot be activated simultaneously but one after the other.

Also,  the amounts and activities of the distinctive enzymes of each pathway are controlled so that both pathways are not highly active at the same time

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