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Describe how IdeS and/or rozanolixizumab could be used in conjunction with traditional immunosuppression protocols and in...

Describe how IdeS and/or rozanolixizumab could be used in conjunction with traditional immunosuppression protocols and in particular, discuss the consequences when these agents are no longer biologically active.
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IdeS also known as Imlifidase (Ig G degrading enzyme of streptococcus pyrogenes ) is asecreted cysteine endopeptidase from the human pathogen S. pyrogenes with an high degree of substrate speficity catalyzing single proteolytic cleavage at lower hinge of human Ig G.

Rozanolixizumab works by binding with high affinity to human neonatal Fc receptor selectively inhibiting Ig G rescue and recycling. By reducing serum levels of Ig G.

can be used for the treatment of myasthenia gravis a Ig G autoimmune disease.

imlifidase can be used in kidney transplantation to prevent organ rejection in highly sensitized patients

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