What is an SH2 domain, and what role does it play in RTK signaling pathways?
- What is an SH2 domain, and what role does it play in RTK signaling pathways?
Homework Answers
SH2 Domain: It is a domain (An Src Homology domain) that bind to GRB2 ,a specific phosphotyrosine residue in the activated receptor. SH2 domain was identified originally as a conserved amino acid sequence in the non catalytic region of tyrosine kinases encoded by vrial oncogenes. GRB2 has also a domain , SH3 that is bind to activated sos. SH3 binds to proline rich motifs.
SH2 domain is used for activation of Ras and activated in RTKs.
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What is an SH2 domain, and what role does it play in RTK
signaling pathways?
1. How does a PTB domain differ from and SH2 domain? 2. Which signaling pathway evokes...
1. How does a PTB domain differ from and SH2 domain? 2. Which signaling pathway evokes most of the transformation phenotypes induced by the Ras oncoprotein? 3. Briefly explain how the AKT kinase gets recruited to the plasma membrane in response to PI3K signaling 4. How does the PTEN phosphatase negatively regulated AKT kinase?
How does protein modification play a role in cell signaling? Provide three examples.
How does protein modification play a role in cell signaling? Provide three examples.
What is the key activating signal in the TNF receptor signaling pathway that occurs downstream of...
What is the key activating signal in the TNF receptor signaling pathway that occurs downstream of TNF-alpha binding to the extracellular domain? What are the analogous activating signals downstream of receptor activation in the GPCR and RTK pathways.
What is the key activating signal in the TNF receptor signaling pathway that occurs downstream of...
What is the key activating signal in the TNF receptor signaling pathway that occurs downstream of TNF-alpha binding to the extracellular domain? What are the analogous activating signals downstream of receptor activation in the GPCR and RTK pathways.
2. Nucleotides play important roles in cell signaling pathways in all three domains of life. List...
2. Nucleotides play important roles in cell signaling pathways in all three domains of life. List 5 different nucleotides involved in cell signaling. 5 pts.
How does RSTK signal transduction differ from RTK and GPCR signaling? (Drawing a table may help)
How does RSTK signal transduction differ from RTK and GPCR signaling? (Drawing a table may help)
Place the following events in Receptor Tyrosine Kinase signaling in order from the point when the...
Place the following events in Receptor Tyrosine Kinase signaling in order from the point when the RTK binds it ligand. A.) An SH2 domain proteins is recruited to phosphotyrosine residues B.) cytoplasmic tails of the RTKs cross-phosphorylate C.) RAS-GEF catalyzes GTP exchange on RAS D.) Receptors dimerize in the plasma membrane
Support the hypothesis that signaling pathways appeared early in evolution and are well-conserved using the yeast...
Support the hypothesis that signaling pathways appeared early in evolution and are well-conserved using the yeast mating factor as an example. A) Signaling in yeast uses the RTK pathway and is evolutionarily conserved, like epinephrine signaling in humans. B) Signaling in yeast uses G-protein coupled receptors for signaling and is evolutionarily conserved, like epinephrine signaling in humans. C) Signaling in yeast uses an endocrine pathway and is evolutionarily conserved, like epinephrine signaling in humans. D) Mating factor in yeast uses...
Classes 7-8 Cytoplasmic Growth Signaling Be able to describe Ras structure and function. What kind of...
Classes 7-8 Cytoplasmic Growth Signaling Be able to describe Ras structure and function. What kind of protein is it? How is it regulated (Fig. 5.30)? How many forms of Ras do humans express? Be able to describe how Ras interacts with multiple downstream partners. What mechanisms render ras oncogenic? Also, how does Ras become oncogenic in the absence of ras mutations? Be able to describe how Ras interacts with the growth factor receptor signaling machinery. How did fly genetics help...
What role would religious beliefs should play in ethical reasoning in the public domain? (at least...
What role would religious beliefs should play in ethical reasoning in the public domain? (at least 3-paragraphs)
2. Nucleotides play important roles in cell signaling pathways in all three domains of life. List 5 different nucleotides involved in cell signaling. 5 pts.
Classes 7-8 Cytoplasmic Growth Signaling Be able to describe Ras structure and function. What kind of protein is it? How is it regulated (Fig. 5.30)? How many forms of Ras do humans express? Be able to describe how Ras interacts with multiple downstream partners. What mechanisms render ras oncogenic? Also, how does Ras become oncogenic in the absence of ras mutations? Be able to describe how Ras interacts with the growth factor receptor signaling machinery. How did fly genetics help...
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