How does protein modification play a role in cell signaling? Provide three examples.
How does protein modification play a role in cell signaling? Provide three examples.
Homework Answers
Often a protein modification acts as a signal for cell processes to occur. Such modification act as stimulus for the downstream pathway and avoid false reactions just in presence of protein and not the modifier.
Eg:
-receptor tyrosine kinases undergo autophosphorylation on binding ligand. phosphorylated receptor then signals downstream pathway
-proteins are ubiquitinated, so they are tagged for proteolysis
-often methylated proteins have had increased/attenuated function, have implications in certain diseases
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How does protein modification play a role in cell
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