What role do three of the loops on the GPCR at the outside of the cell...
What role do three of the loops on the GPCR at the outside of the cell play in the signaling process?
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Together they serve as a binding site for proteins that link receptors to various signaling proteins. |
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Together they serve as a binding site for proteins that link receptors to various effectors in the cell. |
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Together they serve as a ligand-binding site for extracellular signaling molecules. |
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Together they serve as a binding site for cAMP. |
Homework Answers
Three of the loops on the gpcr at the outside of the cell plays togetherly they serve as a ligand binding site for extracellular signaling molecules and after attachment signaling molecule there is a confirmational changes occurred in gpcr, then various intracellular signaling pathways starts.
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What role do three of the loops on the GPCR at the outside of
the cell...
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Help with these bio questions please.Thank you
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GTP-coupled receptors bind and interact with intracellular proteins. These proteins, in turn, each have a specific response in cell signaling. Place the description on the correct location of GPCR signaling. 1st attempt See Hint Plasma membrane GDP GDP GTP GDP leaves and exchanges with GTP, leading to subunit dissociation Ligand occupancy of receptor causes a twist in the transmembran e loops, opening the GTP/GDP pocket of the alpha subunit Inactive heterotrimeric G protein bound to GDP Beta/gamma subunits remain as...
Help with these bio questions please.Thank you
1 Secretory protein leave the cell by b Exoctossthey remain in the cytoplasm c) pinocytosis d) receptor mediated 2 If proteins lack a c) Ras d) Signal-recognition particle b) Sorting signal 3 What purpose does the protein coat serve a) Capture molecules to remain in the cytosol b) Shapes the membrane into a phospholipid bilayer membrane c) Provides extra protection and support to the organelles d) none of these are correct cells response...
1. In paracrine signaling, the signaling molecules affects only: Target cells close to the cell from which it was secreted a. b. Target cells distant from its site of synthesis in cells of an endocrine organ Both a. and b. с. d. None of these 2. Below are listed the events that occur in cell to cell communication. Signal transduction occurs 1. 2. Plasma membrane receptor binds with a ligand A cellular response is effected 3. 4. Ligand is released...
Question 1 (1 point) Vasoconstriction occurs when epinephrine (adrenaline) binds to the a-adrenergic receptor on vascular smooth muscle cells. One way to treat high blood pressure is to administer competitive inhibitors that bind to this receptor. The Kd for binding of epinephrine to this receptor is ~UM. Based on the measured affinity (Kd) of the following drugs for the a-adrenergic receptor, which might be good candidates for high blood pressure medication? Drug A: Kd = 0.6 M; Drug B: Kd...
Drosopholia eye development is an example of cell differentiation directed by signal binding to a receptor tyrosine kinase (RTK). In this pathway, R7 photoreceptor development requires a receptor (SEV, sevenless), which is activated by binding to a plasma membrane bound signal (BOSS, bride-of-sevenless) displayed on the adjacent R8 cell Receptor activation leads to activation of RAS via two proteins, Drk (down- stream of receptor kinases) and Sos (son-of-sevenless). Activated RAS leads to activation of a phosphorylation cascade that activates the...
Cell Signaling Pathways A Case Study Approach L. Emtage, L Bradbury, N. Coleman, D. Davenport. A Dunning and Grew Assignment. The Wnt/f-catenin pathway B-catenin B-catenin TO Note: GSK3, APC and Axin together are called the B-catenin Destruction Complex DSH is the abbreviation for Dishevelled. The human genome encodes many Fzd receptors, several Dsh proteins, one GSK3, and one ß-catenin. Questions 1. What are the components of the receptor complex? What is the ligand? 2. What is the molecular function of...
Cell Signaling Pathways A Case Study Approach L. Emtage, L Bradbury, N. Coleman, D. Davenport. A Dunning and Grew Assignment. The Wnt/f-catenin pathway B-catenin B-catenin TO Note: GSK3, APC and Axin together are called the B-catenin Destruction Complex DSH is the abbreviation for Dishevelled. The human genome encodes many Fzd receptors, several Dsh proteins, one GSK3, and one ß-catenin. Questions 1. What are the components of the receptor complex? What is the ligand? 2. What is the molecular function of...
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