Vemurafenib prevents proliferation of certain cancer cells that are resistant to treatment with either Cetuximab or...
Vemurafenib prevents proliferation of certain cancer cells that are resistant to treatment with either Cetuximab or Herceptin. Which of the following "genetic signatures" obtained from sequencing ctDNA would indicate that you could effectively treat an individual with Vemurafenib? (The absence of a superscript next to the indicated gene means it's a wild type allele)
A. KRASD + B-RAF
B. KRAS + B-RAFV600E
C. KRASD + B-RAFV600E
D. KRASD + p61B-RAFV600E
E. (a) & (b)
F. (a) & (c)
G. (a) & (d)
H. (b) & (c)
I. (b) & (d)
Homework Answers
THE ANSWER TO THE QUESTION IS : B (KRAS + B-RAFV600E)
Vemurafenib is the main drug of choice in case of patients with BRAF V600E mutation that leading to unresectable or metastatic melanoma. Infact this drug should not be used for diseaes with wild type BRAF melanoma.
BRAF is a well describes oncogene, which is mutated in 15% of almost all types of cancers mainly melanoma, PTC(papillary thyroid carcinoma) and hairy cell leukemia. Of all, V600E is the most common. Studies show that 3% of all tumors consist of B RAF alteration along with alteration in KRAS (wild type) which suggest vemurafenib treatment.
other options are not valid as others are subtypes of KRAS and not wild type, keeping in mind BRAF is not in its wild type and specifically conforms to V600E.
Add Answer to:
Vemurafenib prevents proliferation of certain cancer cells that
are resistant to treatment with either Cetuximab or...
explain 1 or 2 molecular details in how epigenetics may allow melanoma cells to outsmart BRAF inhibitors **This is for a genetics course Seope: This science commentary claims that epigeneties pl...
explain 1 or 2 molecular details in how epigenetics may allow
melanoma cells to outsmart BRAF inhibitors
**This is for a genetics course
Seope: This science commentary claims that epigeneties plays a role in cancer cells becoming therapy-resistant. The language used is generalized for the non-scientist and does not include any molecular details, such as methylation of a specific nucleotide in an allele or modification of a specific histone tail amino acid. Your task (individually or in a group of...
3. Cancer cells undergo rapid unrestrained proliferation. The increased reliance of cancer cells upon glycolysis therefore...
3. Cancer cells undergo rapid unrestrained proliferation. The increased reliance of cancer cells upon glycolysis therefore seems paradoxical, since glycolysis generates only 2 ATP from each glucose molecule, whereas complete oxidative respiration of glucose generates up to 36 ATPs per molecule. Which of the following best explains why glycolysis may be advantageous to rapidly proliferating cancer cells? a. Glycolysis generates NADH that can be used as a source of reducing power for macromolecular synthesis. b. Glycolysis produces intermediates that can...
Herceptin can be used to block hormone receptors on HER2+ cancer cells. Select one: a. True...
Herceptin can be used to block hormone receptors on HER2+ cancer cells. Select one: a. True b. False Jess has been diagnosed with cancer at the age of 42. Further testing reveals that their healthy cells have Select one: a. mutations in growth factor genes O b. an inherited oncogene c. an inherited mutation in a DNA Repair Gene d. a chromosome pair with inherited mutations in a TSG
2) Given that E6 inactivates p53-dependent pathways, cervical cancer cells are particularly resistant to traditional treatments...
2) Given that E6 inactivates p53-dependent pathways, cervical
cancer cells are particularly resistant to traditional treatments
such as chemotherapy, the search is ongoing for new alternative
therapeutics to be used in conjunction with current
chemotherapeutic drugs. One such candidate is the plant flavonoid
Luteolin. In 2014, Ham et al evaluate the effectiveness of Luteolin
on sensitizing cervical cancer cells to apoptosis.
a) In Figure 1, panel A, the researchers looked for an effect on
E6 levels post Luteolin treatment. What...
QUESTION The rough-skinned newt, Taricha granulosa, is a common prey species for garter snakes, Thamnophis sirtalis....
QUESTION The rough-skinned newt, Taricha granulosa, is a common prey species for garter snakes, Thamnophis sirtalis. odotoxin biosynthes s in newts is poary understocd, but its mechanism of action is known: the toxin binds to the Voltage-0ated Na channel found on the membrane of nerve cells and bigcks actico pctentias in nerves and muscles Garter snakes that prey on newts become poisoned if they eat TTX-producing newts. However, resistance to TTX has evolved in some garter the votage-gated sodium channel...
1. True or False: Different cells in an individual’s body have different genomes 2. Which of...
1. True or False: Different cells in an individual’s body have different genomes 2. Which of the following describes a genome-wide association study? A) A study that sequenced the genome of an aggressive metastatic breast cancer biopsy from a 22-year-old patient to determine the genetic mutations present B) A study that treated adult somatic cells with a transcription factor to understand how that transcription factor changes gene expression and the cellular phenotype C) A California study that sequenced the CFTR...
9. Rational Treatment of Cancer (16 pts total) You are a cutting edge oncologist who has treated a cancer patient with I...
9. Rational Treatment of Cancer (16 pts total) You are a cutting edge oncologist who has treated a cancer patient with Ireesa. The patient went into remission for several years but their cancer has now come back. You also have a cancer research lab in which you study drugs like Ireesa. You are also in the process of applying to the FDA for approval for a new clinical trial but you must first answer the following questions: a) What type...
Please complete the chart using the attached electrophoresis results CAUTION: UV light is a mutagen! 5....
Please complete the chart using the attached electrophoresis
results
CAUTION: UV light is a mutagen! 5. Analyze the bands of DNA seen in each lane. The wild-type p53 allele is represented by an approximate size of 3,000 bp. The mutant p53 allele is represented by two bands, approxim bp and 700 bp in length. on #of Bands (and Sizes) p53 Genotype Lane Tube Sample p53 /p53* B Normal DNA (Control) 1 (3,000 bp) 2 DNA from Patient's /3,000 bP 3...
6. The exact location of a gene on a. ploidy b. allele c. locus d. bud...
6. The exact location of a gene on a. ploidy b. allele c. locus d. bud e. karyotype cell cycle are mutated, and might not function proper a. It may result in uncontroliled cell divisionigrowth. b. It may lead to genetic abnormalities that can be passod on to of the following statements are true when the genes controlling the carrying the mutant allele d. It may indicate the need for genetic testing e. All of the above are true. C....
Part III: Dr. Hernandez sits down with Ann and her partner. The doctor is sorry to...
Part III: Dr. Hernandez sits down with Ann and her partner. The doctor is sorry to report that Ann has breast cancer; however, because it was caught early and responds to estrogen and progesterone, the prognosis is good. At this point it looks like the cancer is stage 1. However, as Ann is young, the doctor wants to perform a couple tests. The first test is a genetic sequencing test for BRCA1 and BRCA2, as well as testing for other...
explain 1 or 2 molecular details in how epigenetics may allow
melanoma cells to outsmart BRAF inhibitors
**This is for a genetics course
Seope: This science commentary claims that epigeneties plays a role in cancer cells becoming therapy-resistant. The language used is generalized for the non-scientist and does not include any molecular details, such as methylation of a specific nucleotide in an allele or modification of a specific histone tail amino acid. Your task (individually or in a group of...
Herceptin can be used to block hormone receptors on HER2+ cancer cells. Select one: a. True b. False Jess has been diagnosed with cancer at the age of 42. Further testing reveals that their healthy cells have Select one: a. mutations in growth factor genes O b. an inherited oncogene c. an inherited mutation in a DNA Repair Gene d. a chromosome pair with inherited mutations in a TSG
2) Given that E6 inactivates p53-dependent pathways, cervical
cancer cells are particularly resistant to traditional treatments
such as chemotherapy, the search is ongoing for new alternative
therapeutics to be used in conjunction with current
chemotherapeutic drugs. One such candidate is the plant flavonoid
Luteolin. In 2014, Ham et al evaluate the effectiveness of Luteolin
on sensitizing cervical cancer cells to apoptosis.
a) In Figure 1, panel A, the researchers looked for an effect on
E6 levels post Luteolin treatment. What...
QUESTION The rough-skinned newt, Taricha granulosa, is a common prey species for garter snakes, Thamnophis sirtalis. odotoxin biosynthes s in newts is poary understocd, but its mechanism of action is known: the toxin binds to the Voltage-0ated Na channel found on the membrane of nerve cells and bigcks actico pctentias in nerves and muscles Garter snakes that prey on newts become poisoned if they eat TTX-producing newts. However, resistance to TTX has evolved in some garter the votage-gated sodium channel...
Please complete the chart using the attached electrophoresis
results
CAUTION: UV light is a mutagen! 5. Analyze the bands of DNA seen in each lane. The wild-type p53 allele is represented by an approximate size of 3,000 bp. The mutant p53 allele is represented by two bands, approxim bp and 700 bp in length. on #of Bands (and Sizes) p53 Genotype Lane Tube Sample p53 /p53* B Normal DNA (Control) 1 (3,000 bp) 2 DNA from Patient's /3,000 bP 3...
6. The exact location of a gene on a. ploidy b. allele c. locus d. bud e. karyotype cell cycle are mutated, and might not function proper a. It may result in uncontroliled cell divisionigrowth. b. It may lead to genetic abnormalities that can be passod on to of the following statements are true when the genes controlling the carrying the mutant allele d. It may indicate the need for genetic testing e. All of the above are true. C....
Most questions answered within 3 hours.
-
Slow 'n Steady, Inc., has a stock price of $30, will pay a
dividend next year...
asked 9 minutes ago -
During the current financial year, the owner of Omega
Enterprises withdrew supplies of $2,000 for personal...
asked 5 minutes ago -
PLEASE SHOW MATH CALCULATION(formulas)it has to be done on excel
P12-4 Last year (2016), Richter Condos...
asked 13 minutes ago -
A couple of small ice cubes at 0 °C are added to glass of warm
water...
asked 5 minutes ago -
Regarding language development, which of the following
statements is FALSE?
Babies are able to cry from...
asked 7 minutes ago -
A machine shop owner wishes to assign each of three machinists
(labeled 1, 2, and 3)...
asked 7 minutes ago -
A 0.25μF capacitor is charged to 50 V . It is then connected in
series with...
asked 29 minutes ago -
Calculate the current, I, through the batteries for:
- a 2-bulb parallel circuit
- How does...
asked 30 minutes ago -
Choose the sentence that uses correct punctuation.
1a. The prefatory parts of a report include the...
asked 37 minutes ago -
For the element arsenic, which one of the following sets of
quantum numbers could not apply...
asked 46 minutes ago -
Compare and contrast the architectures of 3 types of ADCs:
Flash, SAR, and pipelined. Use the...
asked 47 minutes ago -
Given P(A) = 0.40, P(B) = 0.50, P(A ∩ B) = 0.15. Which of the
following...
asked 51 minutes ago