1. Are response elements always on stem loop structures of either 5' or 3'-UTRs? 2. If...
1. Are response elements always on stem loop structures of either 5' or 3'-UTRs?
2. If restriction of the SGLT1 causes glucose to remain undigested in the GI tract to remain there, then how is Phlorizin (an SGLT1 and SGLT2 inhibitor) any better than just a SGLT 1 inhibitor?
Homework Answers
1. YES. The response elements are on stem loop structures. The 5'UTRs and 3'UTRs is highly conserved and cis acting RNA element is present for replication. The 5' an form stem loop structure with nucleotides 5-20. Also, 5' stem loop RNA modulate translation of RNA.
2. Phlorizin is better as sodium glucose co-transporter - 1 & 2 (SGLT-1 & SGLT-2) is dual inhibitor and play very important role in elucidating the process of renal glucose absorption. When treatment is given with Phlorizin it induces the excretion of urinary glucose and also helps to lower the plasma glucose level.
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