Many patients become resistant to HIV protease inhibitors with the passage of time owing to mutations in the HIV gene that encodes the protease. Provide a detailed rationale for the observation that mutations are not found in the active site aspartate residues.
Many patients become resistant to HIV protease inhibitors with the passage of time owing to mutations...
Biochemistry chapter9 problem 15 (Berg, 8th) 45 Viva la resistance. Many patients become resistant to HIV protease inhibitors with the passage of time owing to mutations in the HIV gene that encodes the protease Mutations are not found in the aspartate residue that inter- acts with the drugs. Why not? Jiam
Under typical conditions, many essential biochemical reactions proceed so slowly that life could not exist without the presence of enzymes. Enzymes increase reaction rates through a wide variety of mechanisms. These mechanisms generally utilize the following strategies: improving the nucleophiles and electrophiles present in the catalytic R groups or substrates; stabilizing the extra electron density of the leaving group; and stabilizing transition states. Proteases are enzymes that break down proteins by hydrolyzing peptide bonds. Chymotrypsin is a protease found in...
10. Write a one-page summary of the attached paper? INTRODUCTION Many problems can develop in activated sludge operation that adversely affect effluent quality with origins in the engineering, hydraulic and microbiological components of the process. The real "heart" of the activated sludge system is the development and maintenance of a mixed microbial culture (activated sludge) that treats wastewater and which can be managed. One definition of a wastewater treatment plant operator is a "bug farmer", one who controls the aeration...
Risk management in Information Security today Everyday information security professionals are bombarded with marketing messages around risk and threat management, fostering an environment in which objectives seem clear: manage risk, manage threat, stop attacks, identify attackers. These objectives aren't wrong, but they are fundamentally misleading.In this session we'll examine the state of the information security industry in order to understand how the current climate fails to address the true needs of the business. We'll use those lessons as a foundation...
1. Oral acetaminophen has been ordered for a young child who has a fever. A liquid form has been obtained by the nurse to increase the chance of problem free administration. Prior to administration, the nurse is going through the rights of medication administration. When confirming the right dose, what term is the most appropriate? a. "160 mg" b. "one teaspoon" c. "one third of a tablespoon d. "SmL 2. A pregnant woman asks why she needs to take a...