Question

6.) Provide short answers for the questions about protein structure below:

a.) True or False, amino acid sequence defines the native structure of protein.

b.) What is the main type of bonding responsible for stabilizing the secondary structure of proteins?

c.) Briefly discuss the thermodynamics of protein folding into its native 3D structure. Is this process enthalpy driven or entropy driven?

d.) Give an example of 2 major secondary structural motifs found in polypeptides. Do any of these motifs appear in more than one form? If so, what names are used to describe these two forms and which of the two is more stable.

e.) Briefly describe the difference in structure between a globular protein and a fibrous protein. Ina addition, provide 2 examples of a globular protein and 2 examples of a fibrous protein.

f.) Briefly describe the function chaperone protein. In addition, give an example of a specific chaperone protein and describe its function.

g.) Briefly describe the function of a heat shock protein. In addition, give an example of a specific heat shock protein and describe its function.

h.) Briefly describe the forces involved in the formation of a polypeptides primary, secondary and tertiary structure.

I.)Briefly describe the forces involves in the formation of a proteins quaternary structure.

J.) Briefly discuss the different methods that can be used to denature a protein and discuss how each method leads to the proteins denaturing.

K.) Give a specific example of how highly acidic conditions can lead to the destabilization of an alpha-helix. In addition, give an example of how highly basic conditions can lead to the destabilization of an alpha-helix.

Answer 1