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What fraction of Glycine is in the non-charged form at pH= 7. Use pKa values 2...

What fraction of Glycine is in the non-charged form at pH= 7. Use pKa values 2 and 9 to approximate.

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Answer #1

For the simplest amino acid, glycine, pKa1= 2.34 and pKa2 = 9.6, pI = 5.97. The pI will be at a lower pH because the acidic side chain introduces an "extra" negative charge. So the neutral form exists under more acidic conditions when the extra -ve has been neutralized

The glycine has an overall charge of -1. The isoelectric point or the pI is the pHwhere the molecule is electrically neutral ie. its overall charge is 0. The majority ofglycine molecules will have an overall charge of 0 between the pHs of 2.2 and 9.6.

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