Why is acetaminophen soluble in 5% NaOH, but phenacetin is not? Equation? "WILL RATE AS...
Homework Answers
acetaminophen contains hydroxyl group (-OH), which can react with NaOH to form the sodium salt of acetaminophen. the sodium salt of acetaminophen is soluble in water. while the phenacetin doesn't contain the OH group, thus cannot undergo such reaction as above. thus, it is not soluble in 5% NaOH.
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Why is acetaminophen soluble in 5% NaOH, but phenacetin is not? Equation? "WILL RATE AS...
Acetaminophen is soluble in 5% aqueous NaOH, but phenacetin is not. Why the difference?
Acetaminophen is soluble in 5% aqueous NaOH, but phenacetin is not. Why the difference?
Conversion of Acetaminophen into Phenacetin Write the chemical equation Calculate the millimoles contained in 1.30 g...
Conversion of Acetaminophen into Phenacetin Write the chemical equation Calculate the millimoles contained in 1.30 g of acetaminophen and in 2.50 g of K2CO3. What volume of ethyl iodide corresponds to 1.8 g? Why is acetaminophen soluble in 5% aqueous NaOH, while phenacetin is not? Calculate the theoretical yield of phenacetin.
In the synthesis of phenacetin from acetaminophen, an alcohol is converted to an ether. a. Is...
In the synthesis of phenacetin from acetaminophen, an alcohol is converted to an ether. a. Is the–OH in acetaminophen a nucleophile or electrophile? b. What is the function of the ethanol/NaOH? c. What is the function of the CH3 CH2I? d. Describe the mechanism of this reaction.Identify the nucleophile in each step. Use curved arrows to show bondsbreaking and forming. What is the leaving group? e. Would you get phenacetin by treating acetaminophen with sulfuric acid followed by ethanol? Give...
Synthesis of Acetaminophen Postlab Questions During the crystallization of acetaminophen, why was...
Synthesis of Acetaminophen Postlab Questions During the crystallization of acetaminophen, why was the mixture cooled in an ice bath? 1. In the reaction between p-aminophenol and acetic anhydride to form acetaminophen, 0.450 mL of water was added. What was the purpose of the water? 2. Why should you use a minimum amount of water to rinse the conical vial while transferring the purified acetaminophen to the Hirsch funnel? 3. If 0.130 g of p-aminophenol is allowed to react with excess...
although acetanilide and phenacetin aren't appreciably acidic, acetaminophen(like aspirin) is a stronger acid than water.what problem...
although acetanilide and phenacetin aren't appreciably acidic, acetaminophen(like aspirin) is a stronger acid than water.what problem would you encounter if the unknown component were acetaminophen rather than acetanilide or phenacetin, and you extracted the aspirin with 5% NaOH? explain, giving equations for any relevant reactions.
kPlease be very clear in the answer and explain everything explicitly In this experiment, phenacetin will...
kPlease be very clear in the
answer and explain everything explicitly
In this experiment, phenacetin will be prepared by the treatment of acetaminophen of iodoethane in the presence of base under reflux. The acidic nature of the of phenolic group allows the deprotonation by the carbonate species followed by alkylation via an SN2 attack on the electrophilic carbon of an alkyl halide. H К.СО, CH3CH2 2-butanone reflux, 1 h NH HN EFullscreen phenacetin acetaminophen Post-Lab Questions 1. What role does...
for the reaction: acetaminophen + (NaOH/EtOH note: etoh is ethanol) and butyl iodide ---------------> 4-butoxyacetanilide a)...
for the reaction: acetaminophen + (NaOH/EtOH note: etoh is ethanol) and butyl iodide ---------------> 4-butoxyacetanilide a) The first step in this reaction is to reflux acetaminophen in a NaOH/EtOH solution, followed by the addition of butyl iodide. What is the purpose of using the NaOH/EtOH solution? Would the SN2 reaction still occur if the first step was not completed? Why or why not? b) Upon completion of the reaction (before filtration), an additional 4.0 mL of 1.0 M NaOH/EtOH was...
1) Is p-Nitrophenol soluble in water? Why or why not? 2) Is p-Nitrophenol soluble in dilute...
1) Is p-Nitrophenol soluble in water? Why or why not? 2) Is p-Nitrophenol soluble in dilute HCl? Why or why not? 3) Is p-Nitrophenol soluble in dilute NaHCO3? Why or why not? 4) Is p-Nitrophenol soluble in dilute NaOH? Why or why not?
The first step in this reaction is to reflux acetaminophen in a NaOH/EtOH solution, followed by the addition of but...
The first step in this reaction is to reflux acetaminophen in a NaOH/EtOH solution, followed by the addition of butyl iodide. What is the purpose of using the NaOH/EtOH solution? Would the S2 reaction still occur If the first step was not completed? Why or why not? [2 Marks]
Write a mechanism acetaminophen is reacted with NaOH in ethanol to produce C8H8N02 which is then...
Write a mechanism acetaminophen is reacted with NaOH in ethanol to produce C8H8N02 which is then reacted with tert-butyl iodide . What does this produce and what is the mechanism for the entire process?
Synthesis of Acetaminophen Postlab Questions During the crystallization of acetaminophen, why was the mixture cooled in an ice bath? 1. In the reaction between p-aminophenol and acetic anhydride to form acetaminophen, 0.450 mL of water was added. What was the purpose of the water? 2. Why should you use a minimum amount of water to rinse the conical vial while transferring the purified acetaminophen to the Hirsch funnel? 3. If 0.130 g of p-aminophenol is allowed to react with excess...
kPlease be very clear in the
answer and explain everything explicitly
In this experiment, phenacetin will be prepared by the treatment of acetaminophen of iodoethane in the presence of base under reflux. The acidic nature of the of phenolic group allows the deprotonation by the carbonate species followed by alkylation via an SN2 attack on the electrophilic carbon of an alkyl halide. H К.СО, CH3CH2 2-butanone reflux, 1 h NH HN EFullscreen phenacetin acetaminophen Post-Lab Questions 1. What role does...
The first step in this reaction is to reflux acetaminophen in a NaOH/EtOH solution, followed by the addition of butyl iodide. What is the purpose of using the NaOH/EtOH solution? Would the S2 reaction still occur If the first step was not completed? Why or why not? [2 Marks]
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