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The phenomenon in D.MElanogaster known as Position effect variegation (PEV) provides useful evide...

The phenomenon in D.MElanogaster known as Position effect variegation (PEV) provides useful evidence that : (select all that apply)

-chromatin structure is able to regulate gene expression

-Dna is the genetic material

-post-transcriptional mechanism regulate gene expression

-transcriptional mechanisms regulate gene control

-chromatin structure is unable to regulate gene control.

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  • Heterochromatin is necessary for the expression of heterochromatic genes and inhibitory for the expression of euchromatic genes. These two properties of heterochromatin have been elucidated from the study of chromosome rearrangements that induce position effect variegation (PEV) in Drosophila melanogaster. Novel euchromatin-heterochromatin junctions can affect the expression of euchromatic and heterochromatic genes located several megabases away, distinguishing higher-order chromatin structure from most other regulatory mechanisms. Therefore, it can be concluded that chromatin structure is able to regulate gene expression.
  • PEV explains that heritable changes in gene expression can occur without accompanying changes in the DNA sequence. The discovery of position–effect variegation (PEV) by H. J. Muller in 1930 provided the first description of a phenomenon with an underlying epigenetic basis. Therefore, it can be concluded that DNA is the genetic material(as PEV is heritable).
  • In PEV, a gene is positioned in a different part of the chromosome so as to silence the gene expression. This implies that transcription is OFF and therefore, post-transcriptional modifications will not play a role in gene regulation. Rather, post-translational modifications play an important role in the proper formation of the chromatin inturn regulation the gene expression.
  • A gene is regulated and controlled through the transcriptional mechanisms of the organisms. In PEV, a change in the position of a gene can affect the transcription which in turn affects the gene regulation. Therefore, transcriptional mechanisms regulate gene control.
  • Since we have explained that chromatin structures regulate gene expression, the statement, chromatin structure is unable to regulate gene expression is false.
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