Question

Hundreds of hemoglobin mutations have been described that result from a single amino acid change in the primary sequence of the globin chains. Predict the effects on the following mutations on hemoglobin’s structural stability and function (ability to bind/release oxygen, bind allosteric effectors, etc, as appropriate): a] β-H87Y (hint: H87 in β-globin chain is equivalent to H64 in Mb) b] β-F42R (hint: F42 in β-globin chain is equivalent to F43 in Mb) c] β-K82E (hint: K82 is located in the core of the hemoglobin tetramer)

Answer 1

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