Question

that individuals with Down Syndrome (caused by a triplet of genes at chromosome 21, Trisomy 4. It is seen 21) have a shortened life span. Some of this may be due to cardiovascular defects present in about 80% of individuals. A more modern theory is that the cell cycle of individuals with this condition is cycling faster than individuals without the condition. As such, Down Syndrome patients may have an accelerated epigenetic clock. Describe at least three biochemical/genetic/epigenetic factors that can be attributed to accelerated aging and fast epigenetic clock. Describe specifically how practitioners and scientists can check our epigenetic clock speed

Answer 1

Epigenetic clock helps experts in determining age on the basis of DNA methylation level.

The epigenetic clock speed is measured by horvath epigenetic clock these days. Accuracy level is so high with a little error of approx 3.5 years. It was discovered by Steve Horvath. Clock basically works on methylation group on 353 DNA marker CpG dinucleotides. In embryonic stage it is somewhat 0. basically it predicts age of Tissues and organs. As many of our organs are as old as we are, so it helps with our age determination too.