Down syndrome, or trisomy 21, in humans is caused by an extra copy of the relatively...
Down syndrome, or trisomy 21, in humans is caused by an extra copy of the relatively small, acrocentric 21. Including only chromosome 21, the X chromosome (medium in size and somewhat metacentric) and the Y chromosome (small and acrocentric), draw one possible array of chromosomes in the four sperm cells produced by the complete meiosis of one primary spermatocyte in a male individual with Down syndrome. For the purposes of this question, assume that males with Down syndrome produce normal ratios of sperm cells. (More than one answer is possible.) Be sure to label 21, X and Y through meiosis I and meiosis II.
Homework Answers
The case of trisomy 21 can be shown as follows -
Primary Spermatocytes - Xy (2n)
On meiosis I,
Secondary spermatocytes - Xy (the small acrocentric y does not separated during meiosis I)
On meiosis II,
Spermatids - Xy and Xy (2 copies produced, which will form two sperms)
On spermiogenesis, these form sperms with Xy, which on fusing with the egg will lead to trisomy of chromosome 21.
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Down syndrome, or trisomy 21, in humans is caused by an extra
copy of the relatively...
19) Trisomy 21, or Down syndrome, occurs when there is a nom complement but one (extra)...
19) Trisomy 21, or Down syndrome, occurs when there is a nom complement but one (extra) chromosome 21. Although fertility is reduced in both sexes, females have higher fertility rates than males. Van Dyke et al. (1995; Down Syndrome Research and Practice 3(2):65-69) summarize data involving children born of Down syndrome individuals. Assume that children are born to a female with Down syndrome and a normal 46-chromosome male. What proportion of the offspring would be expected to have Down syndrome?...
If a person has Down Syndrome (Trisomy 21), then the gamete produced by the mother of...
If a person has Down Syndrome (Trisomy 21), then the gamete produced by the mother of that person had: A. 21 copies of chromosome 3. B. three copies of chromosome 21. C. 24 chromosomes. D. 47 chromosomes.
What causes de la Chapelle syndrome (XX male syndrome)? A. It is caused by two nondisjunction...
What causes de la Chapelle syndrome (XX male syndrome)? A. It is caused by two nondisjunction events. The first occurs during meiosis in the mother resulting in an XX egg, and the second occurs during meiosis in the father resulting in a sperm with no X or Y chromosomes. When this sperm fertilizes the egg it results in XX male syndrome. B. SRY is intact but the body is unable to respond to the hormone androgen, which produces the female...
That individuals with Down Syndrome (caused by a triplet of genes at chromosome 21, Trisomy 4. It...
that individuals with Down Syndrome (caused by a triplet of genes at chromosome 21, Trisomy 4. It is seen 21) have a shortened life span. Some of this may be due to cardiovascular defects present in about 80% of individuals. A more modern theory is that the cell cycle of individuals with this condition is cycling faster than individuals without the condition. As such, Down Syndrome patients may have an accelerated epigenetic clock. Describe at least three biochemical/genetic/epigenetic factors that...
Which of the following are TRUE? Select All That Apply Trisomy only occurs to chromosome 13...
Which of the following are TRUE? Select All That Apply Trisomy only occurs to chromosome 13 (Patau syndrome), chromosome 18 (Edward syndrome) and 21 (Down syndrome) since we have never seen individuals with trisomy in other chromosomes Poly-X syndrome is caused by non-disjunction, but Turner syndrome is caused by some othre factors In order for Jacob syndrome to happen, non-disjunction should happen during meiosis II and male X-linked genes affect female, but not male In pedigree analysis, if nother of...
QUESTION 15 Which of the following are TRUE? Select All That Apply Trisomy only occurs to...
QUESTION 15 Which of the following are TRUE? Select All That Apply Trisomy only occurs to chromosome 13 (Patau syndrome), chromosome 18 (Edward syndrome) and 21 (Down syndrome) since we have never seen individuals with trisomy in other chromosomes Poly-X syndrome is caused by non-disjunction, but Turner syndrome is caused by some othre factors In order for Jacob syndrome to happen, non-disjunction should happen during meiosis II and male X-linked genes affect female, but not male In pedigree analysis, if...
2. (5 PTS) You are presented with a patient, named Gerry, who has Down syndrome (trisomy 21). You determine that the no...
2. (5 PTS) You are presented with a patient, named Gerry, who has Down syndrome (trisomy 21). You determine that the nondisjunction event occurred in his mother, named Mary, during meiosis I. a. You are interested in the TPTE gene, which is near the centromere of chromosome 21. Virtually no recombination occurs between the centromere and the TPTE gene. Mary has two different alleles of the TPTE gene. Would Gerry's two chromosome 21s from his mother have the same or...
3. Edwards syndrome is caused by an extra chromosome 18. This may result from primary nondisjunction...
3. Edwards syndrome is caused by an extra chromosome 18. This may result from primary nondisjunction during meiosis. The diagram represents such a meiosis beginning with a diploid cell containing synapsed chromosome 18's (a chromosome 18 bivalent) Assuming primary nondisjunction, draw in chromosome 18 in all of the cells shown, and on the lines provided write the chromosome formula (i.e., the n number) and the total number of chromosomes in every cell. For instance, on the lines by the first...
You are presented with a patient, named Gerry, who has Down syndrome (trisomy 21). You determine...
You are presented with a patient, named Gerry, who has Down syndrome (trisomy 21). You determine the nondisjunction event occurred in his mother, named Mary, during meiosis I. The TPTE gene is on chromosome 21. Mary has two different alleles of the TPTE gene (ex. T and t). Do Gerry's maternally-inherited chromosome 21s have the same or different alleles of the TPTE gene? Do not worry about recombination in this question. Same alleles Different alleles Not enough information to determine...
5. Consider the following three conditions: Trisomy 21, or Down syndrome, is a condition where an...
5. Consider the following three conditions: Trisomy 21, or Down syndrome, is a condition where an individual has an extra copy of Chromosome 21 A Stroke involves the loss of brain function due to disruptions in blood flow to the brain. Albumin Deficiency -low levels a blood protein - is found in some individuals with liver disease. Which of the three conditions above could most likely be treated using products from bacterial transformation? Why?
19) Trisomy 21, or Down syndrome, occurs when there is a nom complement but one (extra) chromosome 21. Although fertility is reduced in both sexes, females have higher fertility rates than males. Van Dyke et al. (1995; Down Syndrome Research and Practice 3(2):65-69) summarize data involving children born of Down syndrome individuals. Assume that children are born to a female with Down syndrome and a normal 46-chromosome male. What proportion of the offspring would be expected to have Down syndrome?...
that individuals with Down Syndrome (caused by a triplet of genes at chromosome 21, Trisomy 4. It is seen 21) have a shortened life span. Some of this may be due to cardiovascular defects present in about 80% of individuals. A more modern theory is that the cell cycle of individuals with this condition is cycling faster than individuals without the condition. As such, Down Syndrome patients may have an accelerated epigenetic clock. Describe at least three biochemical/genetic/epigenetic factors that...
Which of the following are TRUE? Select All That Apply Trisomy only occurs to chromosome 13 (Patau syndrome), chromosome 18 (Edward syndrome) and 21 (Down syndrome) since we have never seen individuals with trisomy in other chromosomes Poly-X syndrome is caused by non-disjunction, but Turner syndrome is caused by some othre factors In order for Jacob syndrome to happen, non-disjunction should happen during meiosis II and male X-linked genes affect female, but not male In pedigree analysis, if nother of...
QUESTION 15 Which of the following are TRUE? Select All That Apply Trisomy only occurs to chromosome 13 (Patau syndrome), chromosome 18 (Edward syndrome) and 21 (Down syndrome) since we have never seen individuals with trisomy in other chromosomes Poly-X syndrome is caused by non-disjunction, but Turner syndrome is caused by some othre factors In order for Jacob syndrome to happen, non-disjunction should happen during meiosis II and male X-linked genes affect female, but not male In pedigree analysis, if...
2. (5 PTS) You are presented with a patient, named Gerry, who has Down syndrome (trisomy 21). You determine that the nondisjunction event occurred in his mother, named Mary, during meiosis I. a. You are interested in the TPTE gene, which is near the centromere of chromosome 21. Virtually no recombination occurs between the centromere and the TPTE gene. Mary has two different alleles of the TPTE gene. Would Gerry's two chromosome 21s from his mother have the same or...
3. Edwards syndrome is caused by an extra chromosome 18. This may result from primary nondisjunction during meiosis. The diagram represents such a meiosis beginning with a diploid cell containing synapsed chromosome 18's (a chromosome 18 bivalent) Assuming primary nondisjunction, draw in chromosome 18 in all of the cells shown, and on the lines provided write the chromosome formula (i.e., the n number) and the total number of chromosomes in every cell. For instance, on the lines by the first...
You are presented with a patient, named Gerry, who has Down syndrome (trisomy 21). You determine the nondisjunction event occurred in his mother, named Mary, during meiosis I. The TPTE gene is on chromosome 21. Mary has two different alleles of the TPTE gene (ex. T and t). Do Gerry's maternally-inherited chromosome 21s have the same or different alleles of the TPTE gene? Do not worry about recombination in this question. Same alleles Different alleles Not enough information to determine...
5. Consider the following three conditions: Trisomy 21, or Down syndrome, is a condition where an individual has an extra copy of Chromosome 21 A Stroke involves the loss of brain function due to disruptions in blood flow to the brain. Albumin Deficiency -low levels a blood protein - is found in some individuals with liver disease. Which of the three conditions above could most likely be treated using products from bacterial transformation? Why?
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