Question

Question 4. Several different human antigens can be detected in blood tests. The following traits were tested for each individual shown below. Assume NO Bombay phenotype or carriers and all blood types assort independently. Rh type K type ABO type μ and 18 codominant, i recessive; MN type Xea) type Duffy type FvA and FyB codominant, Fy recessive to FyA & FyB The phenotvpes for the individuals are shown below Mother Daughter 1 Daughter 2 Alleged father1 Alleged father 2 Alleged father 3 Alleged father 4 Alleged father 5 Alleged father 6 Alleged father 7 Rh+ dominant to Rh K+ dominant to K-; M and N codominant Xg(a) dominant to X(a X-linked Rh FvA FyB EvA FvAB FvB FvA FvAB MN Xsla) Rh Rh MN Xsla) K+ Rh Xgla*) K+ K+ Rh EvA FvAB Which, if any, of the alleged fathers could be the real father to daughter 1? To daughter 2? Your answer should include all alleged fathers; if NONE of the fathers are possible, please indicate Which, if any, of the alleged fathers could be a blood donor to the daughter 1? To daughter 2? Your answer should include all alleged fathers; if NONE of the fathers are possible, please indicate a. b.

Answer 1

A) alleged father 2 may be the father of daughter 1. As daughter 1 blood group is A and father blood group is AB, so it ensure that daughter has taken type A from father while genotype i from mother. Also Rh- from both father alleged 1 and mother. X^g(a+) from father will result in daughter genotype. Also FyB be inherited from father.

In case of daughter 2 none can be father as she has N type while her mother has M type so it can not be possible that daughter can have only N type .

B) in case of daughter 1 no father can donate blood as every father has one allelic difference in their blood type. Like in father 1 Rh+ factor, FyA, in father 2 K+ factor so it can not give blood to K-, in father 3 B blood type, Rh+ in father 4K+ and FyAB factor, in father 5 K+ factor, in father 6 AB type in father 7 B type blood group.

In case of daughter 2 only Father 5 can give blood as all fit for safe transfusion.