Question

Part B Use the structures given in the cycle shown before this part identify the enzymes involved in each step of the citric acid cycle by completing each sentence Match the words in the left column to the appropriate blanks in the sentences on the right. View Available Hint(s) Reset Help isocitrate dehydrogenase aconitase citrate synthase fumarate hydratase succinate dehydrogenase succinyl-CoA synthetase a-ketoglutarate dehydrogenase malate dehydrogenase In step 1, oxaloacetate condenses with acetyl-CoA to form citrate, which is catalyzed by In step 2, the isomerization of citrate to isocitrate through an intermediate, cis-aconitate, is catalyzed by n step 3, the oxidative decarboxylation of isocitrate to produce a-ketoglutarate and CO2 while converting NAD to NADH is catalyzed by In step 4, the enzyme converts a-ketoglutarate to succinyl-CoA by oxidative decarboxylation and reduction of NAD+ to NADH. Step 5, is the conversion of succinyl-CoA to succinate and an energy-rich GTP molecule by the addition of a phosphate group, which is catalyzed by In step 6, the succinate formed from succinyl-CoA is dehydrogenated to fumarate by the flavoprotein enzyme In step 7, the hydration of fumarate to malate is catalyzed by In step 8, malate is dehydrogenated to oxaloacetate in the presence of the enzyme

Answer 1

1. Step one enzyme is Citrate synthase

2. Step two enzyme is aconitase

3. Step three enzyme is isocitrate dehydrogenase

4. Step four enzyme is alpha ketoglutarate dehydrogenase

5. Step five enzyme is succinyl CoA synthase

6. Step six enzyme is succinate dehydrogenase

7. Step seven enzyme is fumarate hydratase

8. Step eight enzyme is malate dehydrogenase

These are the different steps in Citric acid cycle. It occurs in matrix of mitochondria. It is also called as Krebs cycle.