21.HE.B: Captopril is a drug designed to lower systolic blood pressure. When subjects were treated with this drug, their systolic blood pressure readings (in mm Hg) were measured before and after the drug was taken. The results are in the accompanying table on the next page.
(a) Go through “The Drill” for paired t-tests (Use a 0.05 α-level and the corresponding confidence interval.)
The Drill:
The data must be paired. Only use pairing if there is a natural matching. The two-sample t-test and the paired t-test are not interchangeable.
Independence Assumption
For paired data, the groups are never independent. Need differences independent, not individuals Randomization ensures independence.
Normal Population Assumption
Need to assume the differences follow a Normal model.
(b) What p-value do we get if we choose the (incorrect) two-sample test of Chapter 20 instead of the (correct) paired t-test? Will it affect the conclusion?
A |
B |
C |
D |
E |
F |
G |
H |
I |
J |
K |
L |
|
Before |
200 |
174 |
198 |
170 |
179 |
182 |
193 |
209 |
185 |
155 |
169 |
210 |
After |
191 |
170 |
177 |
167 |
159 |
151 |
176 |
183 |
159 |
145 |
146 |
177 |
Paired Data Condition
The data must be paired. Only use pairing if there is a natural matching.
For paired data, the groups are never independent.
Normal Population Assumption
Following table shows the calculations:
Before | After | d=before-after | (d-mean)^2 |
200 | 191 | 9 | 44.89 |
174 | 170 | 4 | 2.89 |
198 | 177 | 21 | 349.69 |
170 | 167 | 3 | 0.49 |
179 | 159 | 20 | 313.29 |
182 | 151 | 31 | 823.69 |
193 | 176 | 17 | 216.09 |
209 | 183 | 26 | 561.69 |
185 | 159 | 26 | 561.69 |
155 | 145 | 10 | 59.29 |
169 | 146 | 23 | 428.49 |
210 | 177 | 33 | 942.49 |
Total | 223 | 4304.68 |
Conclusion We cannot conclude that Captopril drug lowers systolic blood pressure..
Since we fail to reject the null hypothesis so type II error is possible.
(B)
Following is the output of independent sample t test:
Hypothesis Test: Independent Groups (t-test, pooled variance) | ||||||
Before | After | |||||
185.33 | 166.75 | mean | ||||
17.07 | 14.86 | std. dev. | ||||
12 | 12 | n | ||||
22 | df | |||||
18.583 | difference (Before - After) | |||||
256.133 | pooled variance | |||||
16.004 | pooled std. dev. | |||||
6.534 | standard error of difference | |||||
0 | hypothesized difference | |||||
2.84 | t | |||||
.0047 | p-value (one-tailed, upper) | |||||
F-test for equality of variance | ||||||
291.33 | variance: Before | |||||
220.93 | variance: After | |||||
1.32 | F | |||||
.6544 | p-value |
So the p-value is: 0.0047
In this we reject the null hypothesis and conclude that Captopril drug lowers systolic blood pressure..
21.HE.B: Captopril is a drug designed to lower systolic blood pressure. When subjects were treated with this drug, their systolic blood pressure readings (in mm Hg) were measured before and after the...
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