Question

A number of different genetic variations can result in differences in sex differentiation, such that there are biological females who are genetically 46, XY and biological males who are 46, Xx. One example of this is 46, xx SRY-negative males. These individuals do not have an SRY gene in their genome, but often have mutations or other conditions such that they cannot respond to estrogen where testosterone is produced at high levels even without SRY, or other signals are altered such 4. that a male phenotype is seen. (a) Given what you have learned, would you predict that these individuals could respond normally to testosterone? b) Would you predict that all individuals in this group with their varied genetic differences would have similar levels of serum testosterone? Why or why not? Looking at the range of testosterone levels from the graph above, please predict an approximate serum testosterone level for a 46, XX estimate need not be exact.) Please explain your reasoning. (c) SRY-negative male elite athlete. (This

Answer 1

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