The immune system is self-restricted and the self-restriction is seen with immunological responses that involve both the MHC class I and the MHC class II molecules. Define MHC class I and class II restriction, which molecules and cells are involved and which stage of the immune response (stages 1 – 8 in figure 1-7) the class I and class II restriction occurs (pick a stage from figure 1-7, state that stage, and describe the MHC restriction taking place (class I or II and the cells and molecules). Then describe an experiment which shows MHC class I restriction and then an experiment showing MHC class II restriction. Be sure to define, describe and name all antigens, animals, cell, purification systems and assays (readouts) used.
class 1 MHC genes express glycoproteins and MHC molecules, sometimes referred to as MHC antigens on nearly all nucleated cells. each MHC class 1 gene codes for a transmembrane glycoprotein of approximate molecular weight 43 k da, which is referred to as the alpha or heavy chain. it comprises three extracellular domains alpha 1 alpha 2 alpha 3. the alpha 3 domain is highly conserved and interacts with CD8 membrane molecule present on Tc cells. the highest levels of class 1 molecules are expressed by lymphocytes whereas fibroblasts, liver hepatocytes and neural cells expresses very low levels of class 1 MHC molecules.
the T cell molecule CD4 binds to the invariant portion of all MHC class 2 molecules. class 2 MHC gene express MHC molecule constitrutively only on antigen presenting cells.APCs are professional and non professional APCs. professional APCs are Dendritic cells, macrophages, and B lymphocytes. non professional antigen presenting cells are like fibroblasts, thymic epithelial cells, glial cells can be induced to express class 2 MHC molecules or a co stimulatory signal.
The immune system is self-restricted and the self-restriction is seen with immunological responses that involve both the MHC class I and the MHC class II molecules. Define MHC class I and class II res...
Immunology The immune system is self-restricted and the self-restriction is seen with immunological responses that involve both the MHC class I and the MHC class II molecules. Define MHC class I and class II restriction, which molecules and cells are involved and which stage of the immune response (stages 1 – 8 in figure 1-7 on page 20) the class I and class II restriction occurs (pick a stage from figure 1-7, state that stage, and describe the MHC restriction...
Question 15 (2 points) MHC class I interacts primarily to which subclass of T cell Question 15 options: A) CD8 positive B) CD3 positive C) CD4 positive D) CD2 positive Question 16 (2 points) T helper cells generally can stimulate B cells to differentiate into: Question 16 options: A) NK cells and cytotoxic T cells B) memory cells and plasma cells C) anergic cells and effector cells D) NK cells and memory cells E) anergic cells and memory cells Question...
I REQUEST ALL THE ANSWERS PLEASE Question 11 (2 points) Surface markers on pathogens are sometimes referred to as: Question 11 options: A) PRRs B) TLRs C) PAMPs D) Fc receptors E) none of these Question 12 (2 points) In a normal individual, a T cell that interacts with a self-antigen in the thymus will more than likely undergo what process (which answer is best)? Question 12 options: A) apoptosis B) release granules C) activation D) extravasation E) anergy Question...
BIOL 1307.001 GENERAL BIOLOGY II Homework no. 7. Blood and Immune System Blood. For veins, (C) if to veins fach description below, write in the blank (A) if the description best applies to arteries. (V) ( capillaries, (R) red blood cells, (W) white blood cells, (P) platelets, or (B) blood plasma. 1. back-flow valves carries dissolved carbon dioxide (CO2) and waste products for removal 3. carry blood away from heart 4. carry blood toward heart 5. cells that carry oxygen...