In TAG synthesis, why are both DAG and phosphatidate needed?
In TAG synthesis, why are both DAG and phosphatidate needed?
Homework Answers
Answer:
Triacylglycerols (TAG) synthesis pathway require both DAG and phosphatidate because of the following reason:
- TAG synthesis is a multistep process and phosphatidic acid is a key intermediate in triacylglycerol synthesis pathway. Phosphatidic acid is produced by the acylation of glycerol-3-phosphate.
- First step includes the hydrolysis of phosphatidate diacylglycerol (DAG) by a specific phosphatase (Phosphatidate phosphohydrolase).
- Second step in triacylglycerols biosynthesis involves the acylation of DAG intermediate to a triacylglycerol in a reaction that is catalyzed by diglyceride acyltransferase.
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