Imagine there is a co-dominant deleterious new mutation that arises in a population of size 1,000 diploid individuals. This mutation reduces fitness by 0.001 (s=0.001) in the heterozygous state. What is the probability that this mutation will become fixed in the population?
Imagine there is a co-dominant deleterious new mutation that arises in a population of size 1,000 diploid individuals. T...
A new mutation arises in a population of size 10,000 diploid individuals and then quickly increases to a frequency of 20% in the population. The mutation then stays at frequency 20% for 1,000 generations before becoming lost. Describe one scenario of finesses that could give rise to these trajectories. Note, you are allowed to have fitness change over time.
In a very large diploid population, a new mutation arises that improves the probability that the individual it arose in will survive to reproductive maturity by 2.3%. What is the probability that this mutation will become fixed in the population?
Huntington disease is a form of neuromuscular degeneration that results from a dominant mutation on the autosome. The early onset reduces the reproductive fitness of a affected individuals by about 20%. A large study in Michigan estimated that the frequency of the dominant allele is about 5 x10-6. Assume that this population undergoes random mating and is in equilibrium. What is the expected frequency of individuals who carry the dominant allele? What is the estimated mutation rate of the dominant...
For a deleterious mutation with s = −0.001, what is the probability of fixation in a population of size (a) Ne = 10, 000, (b) Ne = 1, 000, and (c) Ne = 100.
Genetics - Question 3 Defining heterozygosity, H, as the probability that two sequences randomly sampled from a population are different, for a diploid species with a population size of N = 1000 individuals and initial heterozygosity H0 = 0.5 ; a neutral mutation rate of u = 10-9, What is the rate of substitution with the above mutation rate? Explain. [5 marks] If, for beneficial mutation A1 the selection coefficient is s = 0.01, what is the probability of substitution...
Question 2 Part A [5 marks] If a new mutation for lactase persistence arises in a human population of size N = 10, what is the probability that the mutation will spread to fixation under each of the following scenarios? i a population with no culture of dairying, where the mutation is neutral ii a population with a culture of dairying, where the mutation has a selective advantage of s 0.1
Question 2 Part A [5 marks] If a new...
Question 3 [20 marks] Defining heterozygosity, H, as the probability that two sequences randomly sampled from a population are different, for a diploid species with a population size of N = 1000 individuals and initial heterozygosity H0 = 0.5 What will the heterozygosity be after 100 generations? [3 marks] How many generations will it take to reduce the heterozygosity by half? [3 marks] With a neutral mutation rate of u = 10-9, what is the equilibrium value of heterozygosity? [3...
you are studying a population of sexual, diploid insects. one particular trait, wing size, is controlled by a single locus with two alleles. The allele for narrow wing size is dominant (N) and the allele for wide wing size is recessive (n). The population you are studying is comprised of 83 NN individuals, 90 Nn individuals, and 83 nn individuals. What is the EXPECTED FREQUENCY OF THE DOMINANT ALLELE (N) AFTER SELECTION? Assume that w11=0.9, w12=1, and w22=0.7. i dont...
In a population, you observe 300 homozygous dominant (AA) individuals, 400 heterozygous (Aa) individuals, and 300 homozygous recessive (aa) individuals. Please show all your work while answer the following questions. What are the observed allele frequencies for this population? • observed dominant allele (A) frequency: • observed recessive allele (a) frequency: What are the observed genotype frequencies for this population? • observed homozygous dominant (AA) genotype frequency: • observed heterozygous (Aa) genotype frequency: • observed homozygous recessive (aa) genotype frequency:...
Imagine that you have a sample of 2 chromosomes in the 2 island model of population structure. Each island has a size 10,000 diploid individuals. Assume that m=0.005. Calculate: (a) The probability of a coalescent event occurring before a migration event if the 2 chromosomes are sampled from the same population. (b) The probability of a coalescent event occurring before a migration event if the 2 chromosomes are sampled from different populations. (c) The probability of a coalescent event occurring...