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Individuals with premutation length repeats in FMR1 may have some of the phenotypes of Fragile X but not others, which i...

Individuals with premutation length repeats in FMR1 may have some of the phenotypes of Fragile X but not others, which is _____________; for example, some individuals may have cognitive deficiencies, while others might have late onset ataxia. In addition, some individuals will have no phenotypes of the condition at all, due to ____________.

a. incomplete penetrance; variable expressivity

b. variable expressivity; incomplete penetrance

c. complete penetrance; variable expressivity

d. variable expressivity; complete penetrance

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Answer #1

1) option a) incomplete penetrances or reduced penetrances: it is the form of penetrance in which not all individuals carrying a deleterious gene express the associated trait or condition,in fragile x we can see transmitted as an Xlinked dominant trait and with reduced penetrance. Variable expressivity:it is the phenomenon of differing clinical features or phenotypes among individuals carrying the same gene allele or genotype.

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