Question

Interactive Case Study # 2 Henderson Hasselbach Relationship

Can you help me find the correct pKa for each compound, and explain which one is the right answer?

(d) Gaba, an important neurotransmitter in the human brain, is represented in different ionization states below. Circle the most dominant form of this compound at pH-7. Show work to justify how you arrived at this answer. To help, a generic pKa table has been provided on the next page but these values can be used for compounds of similar functionality. You will need to find the correct pKa value for each relevant functional group below. [Note: neutral amines (pKa 35) are not acidic enough to be relevant at any cellular pH, but ammonium-like pKa is more useful and can be found in the table provided] H3N H3N он он Work: (d) Gaba, an important neurotransmitter in the human brain, is represented in different ionization states below. Circle the most dominant form of this compound at pH-7. Show work to justify how you arrived at this answer. To help, a generic pKa table has been provided on the next page but these values can be used for compounds of similar functionality. You will need to find the correct pKa value for each relevant functional group below. [Note: neutral amines (pKa 35) are not acidic enough to be relevant at any cellular pH, but ammonium-like pKa is more useful and can be found in the table provided] H3N H3N он он Work:

Answer 1

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