Dopaminergic Agents/Dopamine Agonist
-carbidopa/levodopa (Sinemet, L-Dopa)
Drug cardfor Dopaminergic Agents/Dopamine Agonist -carbidopa/levodopa (Sinemet, L-Dopa)
1) The drug carbidopa enhances the action of the drug levodopa by: inhibiting the conversion of levodopa to dopamine in the basal ganglia. inhibiting the conversion of levodopa to dopamine in the periphery. promoting the conversion of levodopa to dopamine in the basal ganglia. promoting the conversion of levodopa to dopamine in the periphery. 2) Identify a drug that inhibits the metabolism of dopamine. Levodopa Selegiline Bromocriptine Amantadine 3) Constipation is a side effect of opioid use caused by the:...
PN 200 Fundamentals of Nursing II Parkinson's disease - carbidopa-levodopa TR, a 79-year-old man, was diagnosed with Parkinson's disease 10 years ago. During his early treatment he took selegiline. The drug dosage was increased to alleviate symptoms. 1. How does selegiline alleviate symptoms of Parkinsonism? 2. What dietary changes should be made during the time TR takes selegiline? Because TR developed side effects and adverse reactions to selegiline, the health care provider changed the drug to carbidopa-levodopa. (Sinemet) TR asks...
1. Carbidopa is different from L-DOPA due to . . . A. Its ability to prevent the breakdown of 5-HT B. Its ability to prevent the breakdown of Alcohol C. Its ability to keep L-DOPA in the synapses of the brain D. Its ability to reverse neurodegeneration 2. This drug is known to induce sleep-bound insomnia . . . A. Amitriptyline B. Gabapentin® C. Zoloft® D. Triazolam 3. Lab results from a patient on lithium have come to Dr. Hoffer,...
L- DOPA, a treatment given to Parkinsons patients, can produce dyskinesia a negative side effect involving tics or uncontrollable movement patterns, cause 1) L-DOPA activates the indirect pathway of the basal Ganglia. 2) L-DOPA is converted into dopamine in the substantia Nigra. Substancia Nigra neurons then project down the spinal cord and excite alpha motor neuron pools. 3)L-DOPA crosses the low brain barrier (BBB) and travels to the primary motor cortex activating random muscle groups. 4) L-DOPA is taken up...
L-Dopa is a drug used to treat Parkinson's disease. (Write your molecular formula m the following format: C_wH_xS_yO_z) a. What is the molecular formula of L-dopa? b. What is the formula weight of L-dopa? c. What is the molar mass of L-dopa?
Briefly describe the role of MAO-B, COMT, DAT, and L-DOPA in the synthesis and metabolism of dopamine.
Pramipexole is another drug used in the treatment of Parkinson’s disease that, like levodopa, increases the effect of dopamine. An intial adult dose consists of 0.375 mg/day. This is increased by 0.375 mg/day every 5 days for 31 days. How large is the daily dose at the end of 31 days?
Table 3: Dopamine Agonist Treatment Status and Impulse Control Disorder (ICD) Frequencies One or More Current No Current ICDs ICDs 978 No dopamine agonist Dopamine agonist 72 348 1692 Source: Weintraub, D., Koester, J., Potenza, M. N., Siderowf, A. D., Stacy, M., Voon, V., & Lang, A. E. (2010) Impulse control disorders in Parkinson disease: a cross-sectional study of 3090 patients. Archives of neurology, 67(5), 589-595. 4.7 marks] Weintraub et al (2010) conducted a cross-sectional study to investigate the poten...
6. Cocaine is often called an "indirect agonist" of dopamine receptors. Why do you think this term is used? 7. If someone has a somatic mutation that affects their CYP2D6 gene (and thus drug metabolism), is that person's child likely to also have drug metabolism differences? Why?
6. Cocaine is often called an "indirect agonist" of dopamine receptors. Why do you think this term is used? 7. If someone has a somatic mutation that affects their CYP2D6 gene (and thus...
Mrs. Downs is 55 years old when she was diagnosed with PD (Parkinson’s disease). Her initial symptoms were depression, stooped posture, loss of energy, dragging leg, difficulty walking, tremors, and a loss in her arm swing. Her physician started her on Sinemet® (levodopa-carbidopa combination). While discussing her medication history with her, you find out that she takes a B-complex multivitamin that contains B6. She also tells you that her wife has told her to take some of her phenothiazine (an...