Question

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Both Immunoglobulins and the proteins of the MHC complex are.capable of recognizing a very broad range of proteins or peptides associated with pathogens. Their methods of establishing this wide repertoire of recognition is established at the genetic level, but have no similarities in the processes. Create a page response describing the genes of both these effectors, characterizing the steps in the generation of this diversity in Immunoglobulins. Describe the inheritance of MHC genes and how these genes are expressed and regulated. Your response should be about a page long, and should include your explanation of polygeny and polymorphism as it relates to the MHC haplotype of an individual, and also include explanation of affinity maturation and somatic hypermutation with your description of immunoglobulins. MAKE SURE TO COVER EVERY TOPIC IN THE INSTRUCTIONS

Answer 1

Major histocompatibility complex (MHC) is a cell surface receptors that function to prevent antigen peptide fragments to The cells responsible for cell- mediated immune response.. immunoglobulin related in beta-sandwich structure found in protein families.. immunoglobulin domain involved in various functions including immune system..MHC molecules has two groups that is class I molecules in intracellular antigen peptide fragments, class II molecules exogenously desired antigenic peptides to helper T cells..

A gene is a basic unit of inheritance..The phenotype is the physical expression of the Geno type..According to genes individual will vary.which forms different alleles..it follows simple Mendelian patterns with one alleles inherited from the father and other from mother..MHC genes are HCA - A,B and C..The class II has HCA- DR, DP,DQ..each parent has two pair of six MHC alleles..The number of chromosomes in somatic cells it has 22pairs of autosomes and one pair has sex chromosomes..These chromosomes carries these class I and II alleles..so total twelve MHC alleles in each somatic cells..one set of alleles (six) inherited from the mother and the other six from the father..These six alleles each parents are haplotype..

MHC genes are highly polymorphic, that is non-endogenic same genes and molecules with same set of MHC in identical twins.. polymorphic residues that peptide can enter .The evolution of the MHC polymorphism make the population to a new mutated one, because some people having adequate immune response to fit with pathogens, responsible for polymorphism make inheritance in different MHC molecules and this is the antigen receptor..