What does hemoglobin have that myoglobin does not which makes positive cooperatively in binding oxygen possible?
What does hemoglobin have that myoglobin does not which makes positive cooperatively in binding oxygen possible?
Homework Answers
The reason behind this is mainly because of the structural difference between hemoglobin and myoglobin.
Hemoglobin is the oxygen carrying molecule that we can find in human blood. Myoglobin is the oxygen carrying molecule in the muscle tissues. Hemoglobin is a tetramer which means it consists of 4 haem groups. Myoglobin is monomeric and it contains only one haem group. Because of this having only one group it could not show cooperativity in oxygen binding. As said above hemoglobin has four subunits. If one subunit binds to oxygen it increases the other three will do the same.
Usually myoglobins have more affinity towards oxygen rather than hemoglobin. The cooperative behaviour allows hemoglobin to be more efficient in transporting oxygen.
Oxygen binding curve is a plot of fractional saturation (binding sites for oxygen ) verses partial pressure of oxygen.
For myoglobin a hyperbolic curve is obtained it shows the non-cooperativity of myoglobin and a sigmoidal curve is obtained for hemoglobin which shows the positve cooperativity of hemoglobin.
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What does hemoglobin have that myoglobin does not which makes positive cooperatively in binding oxygen possible?
Binding of oxygen to both myoglobin and hemoglobin in causes a conformational change in which a...
Binding of oxygen to both myoglobin and hemoglobin in causes a conformational change in which a proximal histidine is moved toward the plane of the heme ring. In hemoglobin, this results in a sigmoidal O2 binding whereas myoglobin exhibits hyperbolic O2 binding. Explain this difference.
The following results represent the oxygen binding activity of purified myoglobin, purified hemoglobin, and hemoglobin in...
The following results represent the oxygen binding activity of purified myoglobin, purified hemoglobin, and hemoglobin in human blood cells. pO2 (Torr) Fraction of purified myoglobin with O2 pO2 (Torr) Fraction of purified hemoglobin with O2 pO2 (Torr) Fraction of hemoglobin in red blood cells with O2 0.5 0.161 0.1 .00315 10.6 0.10 1.0 0.277 0.35 .0099 19.5 0.30 2.0 0.434 0.794 .0306 27.4 0.50 3.0 0.535 1.748 .0909 37.5 0.70 4.0 0.605 2.884 .24 50.4 0.85 6.0 0.697 4.467 .50...
When binding with oxygen, what type of binding curve does hemoglobin have? Linear Sigmodial Hyperbolic it...
When binding with oxygen, what type of binding curve does hemoglobin have? Linear Sigmodial Hyperbolic it has none
1. How can hemoglobin deliver oxygen to myoglobin in muscle tissue cells? (use oxygen binding curve,...
1. How can hemoglobin deliver oxygen to myoglobin in muscle tissue cells? (use oxygen binding curve, T-state and R-state, sigmoidal, cooperativity, Bohr effect, carbon dioxide, and 2,3-BPG)
Question 24 (2 points) Which is not true about myoglobin and hemoglobin? Hemoglobin binds oxygen in...
Question 24 (2 points) Which is not true about myoglobin and hemoglobin? Hemoglobin binds oxygen in the lungs and myoglobin stores oxygen in muscles Hemoglobin has 4 hemes and myoglobin has one heme Myoglobin is a simple protein made of alpha helices and hemoglobin is a conjugate protein made of alpha helices and beta sheets Hemoglobin is made of 4 myoglobin-like polypeptides
Answer all questions clearly and correctly Find an oxygen binding curve for myoglobin in your textbook....
Answer all questions clearly and correctly
Find an oxygen binding curve for myoglobin in your textbook. How would you describe the shape of this 2. curve? 3. Explore the structure of hemoglobin using Proteopedia, Go to the Proteopedia site (http://www.proteopedia org/wiki/index.php/Main_Page) and search for hemoglobin. On the hemoglobin page, explore the structures and answer the tollowing questions. Note that you can rotate the hemoglobin molecule using your mouse and that clicking on green links changes the image of the structure....
1. What does it mean to have positive cooperatively in protein-ligand binding? 2. The protein “Mariota”...
1. What does it mean to have positive cooperatively in protein-ligand binding? 2. The protein “Mariota” binds to the ligand “football” with an association rate of 8.0 x 10 103M-1s-1 and an overall dissociation constant, Kd of 10 nM. Calculate the dissociation rate, kd, including appropriate units. 3. An antibody binds to an antigen with a Kd of 8 X 10-6M. At what concentration of antigen will the fractional saturation (Υantigen) be (a) 0.2, (b) 0.5, (c) 0.6, and (d)...
Which five statements about hemoglobin and myoglobin structure are true? Both hemoglobin and myoglobin contain a...
Which five statements about hemoglobin and myoglobin structure are true? Both hemoglobin and myoglobin contain a prosthetic group called heme, which contains a central iron atom. Each iron atom can form six coordination bonds. One of these bonds is formed between iron and oxygen. Heme is composed of an organic protoporphyrin component and a metal atom. By itself, heme is not a good oxygen carrier. It must be part of a larger protein to prevent oxidation of the iron atom....
ter 9. Hemoglobin and Myoglobin Which of these is not found in myoglobin? A) alpha helix...
ter 9. Hemoglobin and Myoglobin Which of these is not found in myoglobin? A) alpha helix b) beta sheetc) heme group, d) globular folding pattern • Which statement about hemoglobin is not true? A) it is globular b) it contains helix loop-helix c) it has three subunits d) it has heme groups · The molecule which binds in the central cavity of hemoglobin when it is deoxygenated is: a) CO2 b) heme c) BPG d) all of these - The...
Chapter 9. Hemoglobin and Myoglobin 1. Which of these is not found in myoglobin? A) alpha...
Chapter 9. Hemoglobin and Myoglobin 1. Which of these is not found in myoglobin? A) alpha helix b) beta sheet c) heme group d) globular folding pattern 2. Which statement about hemoglobin is not true? A) it is globular b) it contains helix- loop-helix c) it has three subunits d) it has heme groups 3. The molecule which binds in the central cavity of hemoglobin when it is deoxygenated is: a) CO2 b) heme c) BPG d) all of these...
Question 24 (2 points) Which is not true about myoglobin and hemoglobin? Hemoglobin binds oxygen in the lungs and myoglobin stores oxygen in muscles Hemoglobin has 4 hemes and myoglobin has one heme Myoglobin is a simple protein made of alpha helices and hemoglobin is a conjugate protein made of alpha helices and beta sheets Hemoglobin is made of 4 myoglobin-like polypeptides
Answer all questions clearly and correctly
Find an oxygen binding curve for myoglobin in your textbook. How would you describe the shape of this 2. curve? 3. Explore the structure of hemoglobin using Proteopedia, Go to the Proteopedia site (http://www.proteopedia org/wiki/index.php/Main_Page) and search for hemoglobin. On the hemoglobin page, explore the structures and answer the tollowing questions. Note that you can rotate the hemoglobin molecule using your mouse and that clicking on green links changes the image of the structure....
Which five statements about hemoglobin and myoglobin structure are true? Both hemoglobin and myoglobin contain a prosthetic group called heme, which contains a central iron atom. Each iron atom can form six coordination bonds. One of these bonds is formed between iron and oxygen. Heme is composed of an organic protoporphyrin component and a metal atom. By itself, heme is not a good oxygen carrier. It must be part of a larger protein to prevent oxidation of the iron atom....
ter 9. Hemoglobin and Myoglobin Which of these is not found in myoglobin? A) alpha helix b) beta sheetc) heme group, d) globular folding pattern • Which statement about hemoglobin is not true? A) it is globular b) it contains helix loop-helix c) it has three subunits d) it has heme groups · The molecule which binds in the central cavity of hemoglobin when it is deoxygenated is: a) CO2 b) heme c) BPG d) all of these - The...
Chapter 9. Hemoglobin and Myoglobin 1. Which of these is not found in myoglobin? A) alpha helix b) beta sheet c) heme group d) globular folding pattern 2. Which statement about hemoglobin is not true? A) it is globular b) it contains helix- loop-helix c) it has three subunits d) it has heme groups 3. The molecule which binds in the central cavity of hemoglobin when it is deoxygenated is: a) CO2 b) heme c) BPG d) all of these...
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