Question

For the video response portion of this assignment, your job will be to state what would happen to the oxygen bond to Hemoglobin if the pH of the tissue was the same as that of the lungs using the logic of the person’s presentation you watched. Discuss whether or not you agree with this.

The video said this:

Oxygen must be transported in the blood from the lungs, because the partial pressure of oxygen (pO₂) is relatively high (approximately 100 torr), than tissues, where the partial pressure of oxygen is much lower (typically 20 torr).

In the lungs, hemoglobin saturated with oxygen approx 98% of the oxygen-binding sites are occupied. On the other hand in tissues, the saturation level drops to 32%.

Oxygen Binding Induces Substantial Structural Changes at the Iron Sites in Hemoglobin

The binding of the oxygen molecule at the sixth coordination site of the iron ion substantially rearranges the electrons within the iron so that the ion becomes effectively smaller, allowing it to move into the plane of the porphyrin. This change is taken place in electronic structure and magnetic properties of hemoglobin, which are the basis for functional magnetic resonance imaging.On oxygen binding, there are substantial changes in quaternary structure that correspond to the T-to-R state transition.

in lungs oxygen binds to haem and in capillaries oxygen dissociate from haem and mix in blood.

A decrease in pH shifts the standard curve towards the right. This occurs because at greater  H⁺ ion concentration, various amino acid residues, such as Histidine stabilize deoxyhemoglobin in the T state.The T state has a lower affinity for oxygen than the R state, so with increased acidity, the hemoglobin binds less O₂ for a given P_O2 (and more H⁺). This is known as the Bohr effect.

as CO2 is acidic in nature so when it interacts with water then the ph of capillaries decreases.

Answer 1

Answer: The content of the video explains about the binding of the oxygen which induces substantial structural changes at the iron site in hemoglobin. Oxygen is one of the substances transported with the assistance of red blood cells. The binding of oxygen is a reversible reaction. And it is explained clearly that the ion becomes effectively smaller, allowing it to move into the plane of the porphyrin. This change is taken place in the electronic structure and magnetic properties of hemoglobin, which are the basis for functional magnetic resonance imaging. Iron associated with the heme binds oxygen. I agree with the content of the video.