A8 The acid dissociation constants (pKa) of the amino acid aspartic acid are shown below. What is the isoelectric p...
I dont really know how to do this question A8 Two acid dissociation constants (pka) of the amino acid aspartic acid are shown below. The measured isoelectric point (pl) is 3.0. What is the pka of the carboxylic acid side chain? PK, 9.8 pk, 2.1 *H3N он Questions continue over page
What is the pI value for aspartic acid, which has pKa values of 2.1, 3.9, and 9.8? The answer is (2.1+3.9)/2 = 3.0 What happen to 9.8?? Why this number is not included?
Aspartic acid has three pKa values, 2.09, 3.86 and 9.82. a. On the following structure for this amino acid circle the protons that can be removed and indicate the corresponding pKa value? b. Determine the value of the isoelectric point for this amino acid. c. Sketch the structure of the zwitterion. d. If electrophoresis is carried out at pH is 7.0, will this amino acid migrate to the anode(+) or cathode(-).
(1) The following diagram represents a titration curve of histidine as pH increases; pKa = 1.82 represents the terminal carboxylic acid group. pK, represents the terminal amino group: 6.0 represents the R-group, and pK, E 9.17 7.59 pH 182 3.0 20 10 H (equivalents) At what point on the diagram is histidine predominantly present as the following species? COO A, at pH < 1.82 B. between pH 1.82 and pH 6.0 C) between pH 6.0 and pH 9.17 D. at...
m ical reactions 8) Which of the following represents an amino acid in a basic solution (pH-11)? A) R-CH-COOR -CH-COOH ENH2 R--CH-COOH R-CH-coo C) NH3 D) 3NH3 9) Which of the following is a zwitterion? B) NH2 R-CH-Coo E) NH2 A) R-CH-COO R-ch-cool R-ca-cooH R-ch-coo H2B) NH2C) NH3 D) NH3 R-ca-coo E) NH2 10) Which of the following amino acids has the lowest isoelectric point? A) glutamic acid B) lysine C) valine D) glycine E) methionine 11) Calculate the isoelectric...
The carboxylic acid group (COOH) in the side chain of Aspartic acid (shown below), one of the 20 naturally occurring amino acids, has a pKa of 4.1. Calculate the percentage of conjugate base (COO- ) for this carboxylic acid group in the side chain of Aspartate at the following pH values: 2.1 , 4.1 and 5.1.
Based on the equilibria shown below, what is the net charge on structure IV? This is a simple problem. Do not overthink it. pk = 2.09 HOQCCH CHCO,H HOCCH CHCO3 *NH *NH II 1 15 PK = 3.86 pk = 9.82 -OCCH_CHCO3- NH2 IV FOCCH2CHCO3- *NH III A) -2 B)-1 C) 0 D) +1 E) +2 At the isoelectric point, the structure of methionine (2-amino-4-methylthiobutanoic acid) is This is a simple problem. Do not overthink it. A) D) CH SCH...
The triprotic form of the amino acid glutamic acid is shown below, along with the pK, value for each ionizable site. B 9.7 l A 2.2 +H3N— C—C—OH c= 0 OH C 4.3 In the monoprotic form of the molecule, is each of the sites (labeled A, B, and C) protonated or unprotonated? site A:( site B: site C: The triprotic form of the amino acid arginine is shown below, along with the pK, value for each ionizable site. B...
2. (10 points) The structure for the amino acid histidine is shown below (at pH 1). Write the chemical equations for the ionic dissociations of histidine (as the pH increases) Determine the isoelectric point for histidine and indicate the structure present at the isoelectric point. The pka values for histidine are 1.82 (-CO2H). 9.17 (NH3'), and 6.00 (R group). OOH "HaN NH "INP
15. Which is used to reduce the disulfide bonds in proteins? D) iodoacetate B) performic acid C) DTT A) PITC 16. What is the net charge on the tripeptide Gly-Asp-Lys at pH 1.5? The table below gives the pKa's of the ionizable groups on the free amino acids. Free amino acid pK, of a-Carboxyl pKs of side chain pKa of a-amino group 2.4 group 9.8 Glycine Aspartate Lysine 2.0 3.9 9.9 2.2 9.1 10.5 A) -2 B) C) D) +2...