Question

65-year-old, received the first unit of a 3-U cross-match that had been ordered by his surgeon after a procedure. Approximately 8 hrs of the transfusion, patient complained of headache and nausea, a slight fever and chills. An investigation into the transfusion reaction showed a negative pretransfusion antibody screen. A post-transfusion specimen was tested, and the same results were obtained. Patient typed as A postive. The donor unit in question was retested and found to be A-positive. The antibody screen on the donor unit was negative and the cross-match was compatible.

1. Does K.F. have a transfusion reaction? If yes, what type of reaction is most likely?

2. What symptoms are associated with this condition?

3. What other conditions present a similar clinical picture early on?

4. Describe 2 possible causes for the tranfusion reaction.

Answer 1

Question 1:

Yes, patient us having hemolytic transfusion reactions.

Question 2:

Signs and symptoms:

Fever

Chills

Headache

Nausea

Dyspnea

flank pain

Skin flushing.

Question 3:

Similar condition:

Immunological reactions.

Allergic response

Question 4:

Causes:

1. Blood mismatch

2. Donar anti body damage immune system.