Question

1. A female patient exhibits a very profound and lengthy menstruation.  The physician examining her decides to run a battery of tests to establish the possible cause for the excessive menstruation.  Analyses of the patient’s blood suggests that a single coagulation factor is low in concentration in the blood.  This factor is made by blood vessel endothelium and is critical in control of blood clotting.  A) What coagulation factor is deficient in this patient?  B) Using any sources you can find (internet or library sources) suggest a possible way to treat this patient for her excessive bleeding.

2. You have been living in Southeast Asia and after some time have been infected with Plasmodium falciparum, the causative agent for malaria.  You are put on a treatment regimen of quinine and seem to successfully reduce the parasite numbers and also recover from the symptomatic phase of the disease.  However, you begin to develop excessive bleeding (nosebleeds and sever bruising) on a routine basis.  A) Based upon this evidence, what do you believe has occurred as a result of the drug therapy?  B) What drug could you administer in an attempt to reverse the bleeding disorder?

3. What are two possible health complications that could arise from a hypercoagulability disorder?

Answer 1

1.

A. The coagulation factor is deficient in the patient is clotting factor VIII deficiency.

B. To treat the patient the female should be given non-steriodal anti-inflammatory drug and trenaxmic acid tablets to treat the patient with heavy blood loss.

2.

A. Based on the evidence, it is clear that quinine drug given to patient cause disseminated intravascular coagulopathy.

B. The drug like non-steriodal drug should be taken in order to reverse the bleeding disorder.

C. The two possible health complications that could arise from hypercougality disorder are reduced number of blood platelets and excessive fibronylsis.