Question
  1. We need to make the following transformation.

    1. Why doesn’t the direct addition of MeMgBr work?

    2. Provide an alternative approach.

  2. Give the structures of the alcohol and the aldehyde or ketone needed to prepare each of the following.

1. We need to make the following transformation. a. Why doesnt the direct addition of MeMgBr work? OH 1. MeMgBr OEt 2. H20 b

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Answer #1

1. Me Mg Br OEU 2. Ho out of keto & ester, ester are more reactive towards Nu substitution with the elimination of alkoxide (

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