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Mrs. Downs is 55 years old when she was diagnosed with PD (Parkinson’s disease). Her initial...

Mrs. Downs is 55 years old when she was diagnosed with PD (Parkinson’s disease). Her initial symptoms were depression, stooped posture, loss of energy, dragging leg, difficulty walking, tremors, and a loss in her arm swing. Her physician started her on Sinemet® (levodopa-carbidopa combination). While discussing her medication history with her, you find out that she takes a B-complex multivitamin that contains B6. She also tells you that her wife has told her to take some of her phenothiazine (an antipsychotic) since she thinks it may “lift her out of her depressed mood”.

A year has passed, and when you see Mrs. Downs again her symptoms have worsened. She is feeling muscle rigidity, fixed facial expressions, slowed movement, arm numbness, and cognitive difficulty. Her physician has changed her Sinemet® to Stalevo® (levodopa-carbidop-entacopone); he has also added a dopamine agonist (such as pramipexole) and an antidepressant for her mood disorders.

  1. Has the prevalence of Parkinson’s disease increased over the last 5 years in Canada? Explain your answer.
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Answer #1

Parkinson's disease affects the nerve cells as s result the dopamine levels are decreased leading to symptoms.

The rate of this disease has gradually increased, the current estimated rate is 1lakh patients are diagnosed with Parkinson disease and every year about 6600 cases are found

Men's are more more prone

People aged 50 and above mostly show some sorts of signs and symptoms

People above 80 years are at greater incidence where nearly 1900 cases are among each 1 million people

In general elders above 60 years of age are at risk of Parkinson's disease in Canada

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