1. What is sonophoresis? 2. What are some of the variables involved in sonophoresis? 3. What...
1. What is sonophoresis?
2. What are some of the variables involved in sonophoresis?
3. What are important factors to consider when preparing pharmaceutical gels?
Homework Answers
Answer: In sonophoresis medication usually consists of hydrophilic molecules and macromolecules which involves method of drug delivery where ultrasound is used to increase the absorption of topical compounds into the epidermis, dermis and skin appendages. Sonophoresis equipment consists of a piezoelectric crystal and a coupling medium and it is operated at intensities of 0.5 to 2 W/cm2.
There are many important factors that have to be considered when preparing pharmaceutical gels such as:
- Regional variation
- Skin hydration
- Skin temperature
- Skin integrity
- Penetration enhancer.
- Occlusivity
- Drug concentration
- pH
- Solubility
- Surfactant
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