Question

Construct a three-step synthesis of 1-bromopropane from propane by dragging the appropriate formulas into the bins. Note that each bin will hold only one item, and not all of the given reagents or structures will be used.

Answer 1

Concept and reason

The concept used to solve this problem is using the given reagents, possible products will be formed in each step and then label it exactly in the given boxes in order to form the exact product.

Here, the starting reactant is propane and the final product is 1-bromopropane.

Fundamentals

NBS is used for the allylic bromination in the presence of peroxide.

Addition of HBr to alkene in the presence of peroxide forms an anti-Markovnikov’s product.

Bromine molecule is used for bromination of alkene. Trans addition takes place.

Bromination of alkane in the presence of sunlight gives radical substitution.

Potassium tertiary butoxide is a sterically hindered base.

The reaction is as follows:

The reaction is as follows:

The reaction is as follows:

HBr adds to alkene to form alkyl bromide in the presence of peroxide.

Ans:

The best reagents used for the synthesis of propane to 1-bromopropane are as follows: