Question

Which of the following solvents would be good to use for 1H NMR analyses? (Check all that apply) acetone-d6 chloroform-d dimethyl sulfoxide deuterium oxide acetone

Answer 1

Concepts and reason

• In nuclear magnetic resonance spectroscopy, the number of non – equivalent protons present in the structure can be identified with the help of proton NMR.

• The compound should be dissolved in solvent and recorded for NMR spectra.

• The solvent that used for dissolving compound should not interfere with the protons present in the compound.

• Therefore, the solvent should be selected in which it should not contain any hydrogen atom. So, deuterated solvents are used in ${}^{\rm{1}}{\rm{H}}$ -NMR.

Fundamentals

The deuterated solvents do not contain any hydrogen atom. Therefore, the solvent cannot interfere with the protons present in it.

The solvents like, acetic acid – d₄, acetone – d₆, Acetonitrile – d₃, Benzene – d₆, chloroform – d, cyclohexane – d₁₇, deuterium oxide, N, N – dimethyl - formamide – d_l, dimethyl sulfoxide – d_G, methanol – d₄, methylene chloride – d₇ are used in NMR.

The solvents like acetone – d_6, chloroform – d and deuterium oxide are used for ${}^{\rm{1}}{\rm{H}}$ -NMR analysis.

The solvents like dimethyl sulfoxide and acetone are not suitable for ${}^{\rm{1}}{\rm{H}}$ -NMR analysis.

Ans:

The solvents that would be good to use for ${}^{\rm{1}}{\rm{H}}$ -NMR analysis are given below:

Acetone – d₆

Chloroform – d

Deuterium oxide