Question

Fenofibrate, a benzophenone derivative, has been used until recently to lower triglycerides and low-density lipoprotein (LDL) cholesterol, thus increasing high-density lipoproteins (HDLs). Starting from benzene and any other necessary reagents, complete the two-step synthesis of the fenofibrate analogue shown below by dragging the appropriate compound(s) into the boxes. Only one set of reagents will fit into each box and not all compounds will be used. (Scroll down to see all the reagents.)

Answer 1

Concepts and reason

This problem is based on the concept of formation of fenofibrate analogue.

Fenofibrate is a derivative of benzophenone which is generally used for the treatment of the patients of cholesterol. It is used to increase the HDL (high-density lipoprotein) in order to decrease the LDL (low-density lipoprotein).

Fundamentals

Benzene is used as the starting material in the formation of fenofibrate analogue. Benzene on reaction sequences gives fenofibrate as the product.

The chemical reaction of first step is given below:

The chemical reaction of the next step is given below:

Ans:

The overall, reaction sequence is given below:

Answer 2