Question

S2 reactions proceed through an inversion of stereochemistry. To illustrate this, show the mechanism, including the transition state of the reaction of methyl iodide with sodium cyanide. 5. For the following pairs indicate which is the stronger nucleophile and why you came to that conclusion 6 Water (H,O) Vs Sodium hydroxide (NaOH) a. b. Potassium lodide (K) vs Potassium Fluoride (KF) Sodium methoxide (NaOCH) Vs. Sodium tert-butoxide (NaOC(CH) 7. A. in an S1 reaction when you double the concentration of the tert-butyl bromide starting mate rial what happens to the rate of the reaction? B. In an S,2 reaction, double the concentration of the 1-bromopentane. What happens to the rate of the reaction? C. Instead, if you double the concentration of the 1-bromopentane and the reagent, sodium acetate, what happens to the rate of the reaction?

Answer 1

. S Nucleophlic substitution Bimolecular SNAeation completes thoraugh inveesion of con figusation as the incaming nucleophile ataek jut pasite (1e') to the leaving g On the Carbon SN is dingle Step pharess haiy ho in tesmedicte only fzans tion State is believed Na CN Sed-cyanide (N.(.-...I IN-C -H H Methyl iodide mthylyanide ond Re eaking mafning Isand han Stute NaI just ffaite steaeadhemis ty metty) cyomidle fotmed y S mechanim has to the seactant mehyl indide due to chage/inveuion in on fgaathon