Are the following examples of general acid/base catalysis, covalent catalysis, catalysis by approximation (proximity effect), or metal-ion catalysis? Complete parts a, b, c, and d.
(b) NMP kinases bring two nucleotides, for example AMP and ATP, together to facilitate the transfer of a phosphoryl group from one nucleotide to the other (creating two ADP). The enzyme positions the adenosine triphosphate (ATP) such that the gamma phosphate group is placed adjacently to the phosphate group of the NMP kinase. This facilitates the transfer of the phosphate between the two molecules.
(c) In aspartate ammonia lyase, a deprotonated serine sidechain
performs a nucleophilic attack on a carbonyl carbon of the
substrate.
(d) An active site histidine abstracts a proton from a substrate,
making it more reactive, then donates the proton back to the
product.
Are the following examples of general acid/base catalysis, covalent catalysis, catalysis by approximation (proximity effect), or...
15. Genetic defect in pyruvate dehydrogenase complex lead a. maple syrup urine disease b. phenyike d. lactic acidemia e. pellagra syrup urine disease b, phenylketonuria c. galactosemia 10. Chemical modification by phosphorylation of pyruvate dehydros a. deactivates the enzyme b. activates the enzyme lation of pyruvate dehydrogenase complex : 17. Pyruvate carboxylase is positively ated through the allosteric mechanism by : a. ATP b. NADH c. Acetyl-SCOA d. TPP e. Biotin 18. Which of the listed coenzymes does not particip...