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Order: Hycamtin (topotecan HCl) 1.5 mg/m2 IV daily for 5 days, repeat every 21 days. The...

Order: Hycamtin

(topotecan HCl) 1.5

mg/m2

IV daily for 5 days, repeat every 21 days.

The label on the vial reads 4 mg, and the manufacturer's directions state: "Reconstitute each 4 mg with 4 mL of sterile water. Withdraw the dose and further dilute in 50 mL

D5W

and infuse over 30 minutes."

Calculate the rate of flow in milliliters per hour for a patient who weighs 92 kg and is 183 cm tall.

A.

100 mL/h

B.

114 mL/h                                       

C.

87.5 mL/h

D.

106 mL/h

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Answer #1

Answer : (D) 106 mL/h

The recommended dose of HYCAMTIN is 1.5 mg/m2 by intravenous infusion over 30 minutes daily for 5 consecutive days, starting on day 1 of a 21-day course.

rate of flow in milliliters per hour for a patient who weighs 92 kg and is 183 cm tall.:

2.16 m2 * 1.5 = 3.24 mg = 3.24 mL;

53 ml/0.5 h = 106 mL/h

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