Note that some of these problems refer to information presented in the Tools of Biochemistry 5A-D.
Sickle cell disease is caused by a so-called "point mutation" in the human β-globin gene. A point mutation is the result of a single base substitution in the DNA encoding a gene. The sickle cell mutation results in substitution of Val for Glu at position 6 in the β-globin protein.
(a) Using the information in Figure 5.18 explain how a point mutation could change a codon for Glu to a codon for Val.
(b) Do you expect the pI for the sickle cell β-globin to be higher or lower than the pI for wild-type β-globin? Explain.
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