Problem

Many biological macromolecules undergo a transition called denaturation. Denaturation is...

Many biological macromolecules undergo a transition called denaturation. Denaturation is a process whereby a structured, biologically active molecule, called the native form unfolds or becomes unstructured and biologically active, The equilibrium is

For a protein at pH = 2 the enthalpy change associated with denaturation is and the entropy change , both at 298.15 K.

a. Calculate the Gibbs energy change for the denaturation of the protein at pH = 2 and T = 303 K. Assume the enthalpy and entropy Ste temperature independent between 298.15 K and 303 K.

b. Calculate the equilibrium constant for the denaturation of protein at pH 2 and T = 303 K.

e. Based on your answer for parts (a) and (b), is the protein structurally stable at pH 2 and T = 303 K?

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