Step-by-Step Solution
Nitrosamines are the compounds (chemical) that have R1N-N=O group. It is a nitros group that is bonded with an amine group. The various nitrosamine groups are carcinogenic in nature. These are used in the manufacturing of pesticides, most rubber products and some cosmetics.
Hansch and his coworkers studied parabolic dependence of the biological activity with log P. Considering other kinds of interactions, such as steric, electronic descriptors along with lipophilic descriptor, a model was proposed. The model was as follows:
In the given equation, a component, which is hydrophobic in nature (positive π value) and has positive σ value (electron withdrawing group) would give high mutagenic activity. π here, indicates the hydrophobicity constant.
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