Solutions For An Introduction to Medicinal Chemistry Chapter 18 Problem 1Q

Log P is the logarithm (log) of partition coefficients of different compounds. π is the lipophilicity substituent constant and is determined by the equation as follows:

In the above equation, P_X is the partition coefficient of the compound with X substituent. P_H is the parent compounds partition coefficient.

In the given case, the log P value for benzene is given as 2.13. Therefore, the log P value for the given structure can be illustrated. The values from the table are 0.52 for CH₃ (methyl) and -0.67 for OH (hydroxyl). The value of log P can be calculated from the equation as follows:

Hence, the value for log P of the given structure is.